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Our interest is focused on the mechanisms underlying the conversion (transduction) of chemical energy contained in the compound ATP into mechanical work by contractile proteins and how these processes becomes dysfunctional in heart failure. For this purpose we study a) biophysical properties of small specimens of cardiac muscle (trabeculae), single cells and myofibrils, and b) the biochemical properties of contractile proteins and signaling molecules using biochemistry and proteomic approaches. Our overall goal is to lay the basic science foundation for the development of new therapeutic strategies to combat the syndrome of congestive heart failure in patients.
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Sukriti Dewan,Namthip Witayavanitkul,Mohit Kumar, Beth J Mayer, Lauren Betancourt,Olivier Cazorla,Pieter P de Tombe
The Journal of general physiologyno. 6 (2023)
Pierre-Edouard Grillet, Elodie Desplanche, Quentin Wynands,Fares Gouzi,Patrice Bideaux,Aurelie Fort,Valérie Scheuermann,Alain Lacampagne,Anne Virsolvy,Jérôme Thireau,Pieter de Tombe,Arnaud Bourdin,
American journal of respiratory cell and molecular biologyno. 2 (2023): 230-241
Archives of Cardiovascular Diseases Supplementsno. 2 (2023): 212
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Jia Li,Joakim Sundnes,Yufeng Hou,Martin Laasmaa,Marianne Ruud,Andreas Unger,Terje R Kolstad,Michael Frisk,Per Andreas Norseng, Limin Yang,Ingunn E Setterberg, Estela S Alves,
Circulation researchno. 3 (2023): 255-270
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