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个人简介
I entered CNRS as a researcher in 2008. Since then, I have combined biochemical, genetic and evolutionary approaches on model micro-organisms to advance our molecular understanding of the biosynthesis and function of respiratory chains, which are central to cellular bioenergetics. For the last 10 years, I mostly focused on the redox lipid ubiquinone/coenzyme Q. CoQ belongs to the family of isoprenoid quinones, compounds that transfer electrons and protons within respiratory chains. My collaborators and I have identified several new genes involved in ubiquinone biosynthesis and we are now trying to obtain the first structure of a CoQ biosynthetic complex. We are also studying the physiology and evolution of the pathway which appeared on Earth more than 2 billion years ago. We have recently extended our research to other isoprenoid quinones, like menaquinone and rhodoquinone. Menaquinone is the most ancient and widespread quinone. Some bacteria, commonly found in the intestinal microbiota, rely on menaquinone but are not able to synthesize it. How quinones might be exchanged within complex bacterial communities is a new topic of interest for us. Given the hydrophobicity of quinones, common mechanisms of metabolites trafficking are inapplicable, so we are trying to reveal the new mechanisms at play.
研究兴趣
论文共 78 篇作者统计合作学者相似作者
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Felix J Elling,Fabien Pierrel, Sophie-Carole Chobert, Sophie S Abby,Thomas W Evans, Arthur Reveillard, Ludovic Pelosi, Juliette Schnoebelen,Jordon D Hemingway,Ahcene Boumendjel, Kevin W Becker,Pieter Blom,
biorxiv(2024)
Katayoun Kazemzadeh Ferizhendi,Philippe Simon,Ludovic Pelosi,Emmanuel Sechet, Roache Arulanandam,Mahmoud Hajj Chehade,Martial Rey, Deniz Onal, Laura Flandrin, Rouba Chreim,Bruno Faivre,Samuel Chau-Duy-Tam Vo,
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICAno. 13 (2024): e2321242121-e2321242121
JOURNAL OF CHEMICAL INFORMATION AND MODELINGno. 13 (2024): 5175-5193
Lucie Gonzalez, Samuel Chau-Duy Tam Vo,Bruno Faivre,Fabien Pierrel,Marc Fontecave,Djemel Hamdane,Murielle Lombard
Chembiochem : a European journal of chemical biologyno. 5 (2024): e202300738-e202300738
Sarah Charital,Serena Shunmugam,Sheena Dass, Anna Maria Alazzi,Christophe-Sebastien Arnold,Nicholas J. Katris,Samuel Duley,Nyamekye A. Quansah,Fabien Pierrel,Jerome Govin,Yoshiki Yamaryo-Botte,Cyrille Y. Botte
Rodrigo Arias-Cartin, Katayoun Kazemzadeh Ferizhendi,Emmanuel Séchet,Ludovic Pelosi,Corinne Loeuillet,Fabien Pierrel,Frédéric Barras,Emmanuelle Bouveret
MBio (2023)
Arias-Cartin Rodrigo, Kazemzadeh Ferizhendi Katayoun,Séchet Emmanuel,Pelosi Ludovic,Loeuillet Corinne,Pierrel Fabien,Barras Frédéric,Bouveret Emmanuelle
bioRxiv (Cold Spring Harbor Laboratory) (2023)
Nathalie Sturm, Morgane Roger-Margueritat,Fabien Pierrel,Philippe Lehours, Muriel Genevay,Bertrand Huard
JOURNAL OF LEUKOCYTE BIOLOGYno. 4 (2023): 376-382
Ludovic Pelosi,Laura Morbiato,Arthur Burgardt,Fiorella Tonello, Abigail K. Bartlett,Rachel M. Guerra, Katayoun Kazemzadeh Ferizhendi,Maria Andrea Desbats,Bérengère Rascalou, Marco Marchi,Luis Vázquez-Fonseca,Caterina Agosto,
Katayoun Kazemzadeh,Ludovic Pelosi,Clothilde Chenal,Sophie-Carole Chobert,Mahmoud Hajj Chehade,Margaux Jullien, Laura Flandrin,William Schmitt,Qiqi He, Emma Bouvet,Manon Jarzynka,Nelle Varoquaux,
MOLECULAR BIOLOGY AND EVOLUTIONno. 10 (2023)
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