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个人简介
Our group has traditionally focused on the elucidation of molecular and biological mechanisms of tumorigenesis, focusing on myeloid leukemia and breast cancer. We have i) identified and characterized several AML-associated genetic alterations (PML-RARa; NPMc+); ii) defined biological mechanisms of tumorigenesis (for example their effect on chromatin) and iii) exploited our findings for the development of novel targeted treatments (retinoic acid, HDAC inhibitors, Lysine demethylase inhibitors). Furthermore, we have defined the underlying molecular (p53 and p21) and biological (symmetric vs asymmetric division) mechanisms contributing to CSC pool maintenance.
More recently, our group has been focusing on the analysis of intratumor heterogeneity, particularly on the study of adaptive responses, with the aim of defining its role during tumor progression and treatment resistance.
Major emphasis is given to explore mechanisms of accumulation of DNA damage in cancer cells.
A parallel line of investigation focuses on the role of the aging gene p66, which we discovered in 1999 as being involved in the regulation of oxidative stress response.
More recently, our group has been focusing on the analysis of intratumor heterogeneity, particularly on the study of adaptive responses, with the aim of defining its role during tumor progression and treatment resistance.
Major emphasis is given to explore mechanisms of accumulation of DNA damage in cancer cells.
A parallel line of investigation focuses on the role of the aging gene p66, which we discovered in 1999 as being involved in the regulation of oxidative stress response.
研究兴趣
论文共 479 篇作者统计合作学者相似作者
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Journal of Translational Medicineno. 1 (2024): 29-29
Nature Communicationsno. 1 (2024): 1-18
Chiara Ronchini,Chiara Caprioli, Gianleo Tunzi, Francesco Furio D'Amico,Emanuela Colombo,Marco Giani,Giuseppe Foti,Donatella Conconi,Marialuisa Lavitrano,Rita Passerini,Luca Pase,Silvio Capizzi,
CANCER PREVENTION RESEARCHno. 2 (2024)
Blood cancer discoverypp.OF1-OF15, (2024)
Cancer researchno. 13 (2023): 2155-2170
Bruno A. Duso,Eleonora Messuti,Giulia Tini,Emanuele Bonetti, Alessia Castiglioni,Gianmaria Frigè,Giuseppe Ciossani,Silvia Monzani,Chiara Soriani, Daria Khuntsariya, Nicolò Roda,Andrea Polazzi,
biorxiv(2023)
bioRxiv (Cold Spring Harbor Laboratory) (2023)
Frontiers in bioinformatics (2023): 1067113-1067113
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