基本信息
浏览量:5
![](https://originalfileserver.aminer.cn/sys/aminer/icon/show-trajectory.png)
个人简介
Research Interests
Phospholipids are the building blocks of biological membranes which enable cells to separate biochemical pathways, establish specialized functions that can respond when appropriate, and adapt to constantly fluctuating metabolic conditions. My laboratory’s research focus is on the underappreciated contribution of the mitochondrion to cellular phospholipid metabolism. In addition to being the sole producer of the canonical mitochondrial lipid, cardiolipin (CL), the mitochondrion hosts one of the two major pathways in a cell for the production of phosphatidylethanolamine (PE). Ablation of the mitochondrial capacity to synthesize either CL or PE is embryonically lethal in mice. Moreover, in the yeast Saccharomyces cerevisiae, the combined absence of CL and PE is synthetically lethal. Using a combination of yeast and mammalian cell culture models, my lab currently has three major ongoing projects centered on different aspects of mitochondrial phospholipid metabolism in health and disease.
Phospholipids are the building blocks of biological membranes which enable cells to separate biochemical pathways, establish specialized functions that can respond when appropriate, and adapt to constantly fluctuating metabolic conditions. My laboratory’s research focus is on the underappreciated contribution of the mitochondrion to cellular phospholipid metabolism. In addition to being the sole producer of the canonical mitochondrial lipid, cardiolipin (CL), the mitochondrion hosts one of the two major pathways in a cell for the production of phosphatidylethanolamine (PE). Ablation of the mitochondrial capacity to synthesize either CL or PE is embryonically lethal in mice. Moreover, in the yeast Saccharomyces cerevisiae, the combined absence of CL and PE is synthetically lethal. Using a combination of yeast and mammalian cell culture models, my lab currently has three major ongoing projects centered on different aspects of mitochondrial phospholipid metabolism in health and disease.
研究兴趣
论文共 177 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Olivia Sniezek Carney, Kodi William Harris, Yvonne Wohlfarter, Kyuna Lee,Grant Butschek,Arianna Anzmann,Steven M Claypool,Anne Hamacher-Brady,Markus Keller,Hilary J Vernon
bioRxiv : the preprint server for biology (2024)
Nanami Senoo, Dinesh Chinthapalli,Matthew Baile, Vinaya Golla,Bodhisattwa Saha,Nathan Alder,Eric May,Carol Robinson,Steven Claypool
Journal of Biological Chemistryno. 3 (2024)
Brenita C Jenkins, Kit Neikirk, Prasanna Katti,Steven M Claypool,Annet Kirabo, Melanie R McReynolds, Antentor Hinton
Trends in biochemical sciencesno. 4 (2024): 346-360
Circulation researchno. 2 (2024): 372-396
Cancer Researchno. 6_Supplement (2024): 6844-6844
Nanami Senoo,Dinesh K Chinthapalli,Matthew G Baile, Vinaya K Golla,Bodhisattwa Saha,Abraham O Oluwole,Oluwaseun B Ogunbona,James A Saba, Teona Munteanu, Yllka Valdez,Kevin Whited, Macie S Sheridan,
The EMBO journalno. 14 (2024): 2979-3008
Phillip Buckhaults,Sana Khalili, Atefeh Mohseninia,Changlong Liu,Carolyn Banister, Sidney Morrison, Paige Heine,Prashanth Gokare,Glenn Cowley,Barbara Weir,David Pocalyko,Kurtis Bachman
crossref(2024)
Mackenzie T. Primrose,Steven M. Claypool
Trends in Endocrinology & Metabolism (2024)
bioRxiv : the preprint server for biology (2024)
Nanami Senoo,Dinesh K Chinthapalli,Matthew G Baile, Vinaya K Golla,Bodhisattwa Saha,Oluwaseun B Ogunbona,James A Saba, Teona Munteanu, Yllka Valdez,Kevin Whited,Dror Chorev,Nathan N Alder,
bioRxiv : the preprint server for biology (2023)
加载更多
作者统计
#Papers: 124
#Citation: 4611
H-Index: 35
G-Index: 67
Sociability: 6
Diversity: 3
Activity: 20
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn