基本信息
views: 8
Career Trajectory
Bio
Having developed a program in breast cancer research, Dr. Koeffler is looking at the molecular causes and novel forms of therapy of the disease. He has secured NIH grant and US Army grant funding for breast cancer. Dr. Koeffler has developed a program in prostate cancer research and is looking at novel forms of therapy. He has begun a clinical trial of 9-cis retinoic acid in the disease. He has secured NIH funding as wellas private philanthropic sources for prostate cancer. Leukemias, preleukemias and lymphomas: Studying the basic biology of these diseases and developing novel forms of therapy including vaccines. He has NIH funding that is used for this research. Dr. Koeffler has cloned a pivotal hematopoietic control gene known asC\EBPs, and now making transgenic and "knockout" mice to define the in vivo activities of this gene. He anticipates writing a major NIH grant for this work. Program of cloning new genes: Dr. Koeffler has recently cloned a cyclinA1 gene and a protein processing gene using molecular biology and genetic techniques, and he is now defining the biology of these genes and their implications to cancer development. He has established a research team that uses computers, data banks and gene libraries to clone rapidly novel, interesting genes. Identification of novel tumor suppressor genes using extensive tumor DNA banks from over twenty tumor types with matched normal control DNA from the same individual and using over 300 microsatellites. Dr. KoefflerÂs group is sublocalizing the site of tumor suppressor genes that are mutated in a variety of cancers. This study is funded in part by the Concern Foundation.
Research Interests
Papers共 1297 篇Author StatisticsCo-AuthorSimilar Experts
By YearBy Citation主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
crossref(2024)
Frances Kusuma,Aishvaryaa Prabhu, Galen Tieo, Syed Moiz Ahmad,Pushkar Dakle,Wai Khang Yong,Elina Pathak,Vikas Madan,Yan Yi Jiang,Wai Leong Tam,Dennis Kappei,Peter Dröge,
Cancer Researchno. 8_Supplement (2024)
Chehyun Nam, Li-Yan Li,Qian Yang,Benjamin Ziman, Hua Zhao, Boyan Hu,Casey Collet, Pei Jing,Qifang Lei,Li-Yan Xu,En-Min Li,H Phillip Koeffler,
Proceedings of the National Academy of Sciences of the United States of Americano. 26 (2024): e2320835121-e2320835121
ADVANCED SCIENCEno. 9 (2024): e2304939-e2304939
Yuan Jiang,Yueyuan Zheng,Yuan-Wei Zhang, Shuai Kong,Jinxiu Dong,Fei Wang,Benjamin Ziman,Sigal Gery,Jia-Jie Hao,Dan Zhou, Jianian Zhou,Allen S. Ho,
NATURE COMMUNICATIONSno. 1 (2024): 2484-2484
crossref(2024)
crossref(2024)
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCESno. 8 (2024): 3140-3155
Jin-Fen Xiao,Ley-Fang Kua,Ling-Wen Ding,Qiao-Yang Sun,Khine Nyein Myint, Xiu-Rong Chia,Nachiyappan Venkatachalam,Xinyi Loh,Jason E. Duex, Vanessa Neang,Siqin Zhou,Ying Li,
crossref(2023)
Load More
Author Statistics
#Papers: 1294
#Citation: 73530
H-Index: 132
G-Index: 132
Sociability: 8
Diversity: 3
Activity: 143
Co-Author
Co-Institution
D-Core
- 合作者
- 学生
- 导师
Data Disclaimer
The page data are from open Internet sources, cooperative publishers and automatic analysis results through AI technology. We do not make any commitments and guarantees for the validity, accuracy, correctness, reliability, completeness and timeliness of the page data. If you have any questions, please contact us by email: report@aminer.cn