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Our laboratory uses a genetic approach in mouse to discover genes, proteins and pathways that play an important role in complex human diseases. Our long-term objectives are to translate knowledge obtained in laboratory mouse models, into clinical outcomes through the creation of novel diagnostic tools or new small molecules modulators with therapeutic value in the corresponding human disease. We are currently focusing on three major human diseases known to have clear genetic component: infectious diseases, cancer, and the birth defect spina bifida. Our genetic platform is based on the use of genetically diverse mouse inbred strains, recombinant congenic strains, and experimentally induced mutagenized mouse stocks (ENU mutants).
Our laboratory uses a genetic approach in mouse to discover genes, proteins and pathways that play an important role in complex human diseases. Our long-term objectives are to translate knowledge obtained in laboratory mouse models, into clinical outcomes through the creation of novel diagnostic tools or new small molecules modulators with therapeutic value in the corresponding human disease. We are currently focusing on three major human diseases known to have clear genetic component: infectious diseases, cancer, and the birth defect spina bifida. Our genetic platform is based on the use of genetically diverse mouse inbred strains, recombinant congenic strains, and experimentally induced mutagenized mouse stocks (ENU mutants).
研究兴趣
论文共 467 篇作者统计合作学者相似作者
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Jean-Frederic Olivier,David Langlais,Thiviya Jeyakumar, Maria J. Polyak,Luc Galarneau,Romain Cayrol,Hua Jiang, Kelly R. Molloy, Guoyue Xu,Harumi Suzuki,John LaCava,Philippe Gros,
Communications Biologyno. 1 (2024): 1-19
Thomas C G Bosch, Mark Wigley, Beatriz Colomina,Brendan Bohannan,Forrest Meggers,Katherine R Amato,Meghan B Azad,Martin J Blaser, Kate Brown,Maria Gloria Dominguez-Bello,Stanislav Dusko Ehrlich,Eran Elinav,
Anna-Lena Neehus,Brenna Carey,Marija Landekic, Patricia Panikulam,Gail Deutsch,Masato Ogishi,Carlos A. Arango-Franco,Quentin Philippot,Mohammadreza Modaresi,Iraj Mohammadzadeh, Melissa Corcini Berndt,Darawan Rinchai,
Yue Liang, Garvit Bhatt,Lin Tze Tung,HanChen Wang, Joo Eun Kim, Marwah Mousa,Viktoria Plackoska,Katalin Illes, Anna A. Georges,Philippe Gros,Linda Henneman,Ivo J. Huijbers,
Anna-Lena Neehus, Marija Landekic,Darawan Rinchai, Patricia Panikulam,Quentin Philippot,Tom Le Voyer,Masato Ogishi,Jeremie Rosain,Mana Momenilandi, Carlos Andres Arango Franco,Marta Martin-Fernandez,Taushif Khan,
EUROPEAN RESPIRATORY JOURNAL (2023)
TRANSFUSION MEDICINE REVIEWSno. 3 (2023): 150748-150748
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