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Work on a classic allosteric enzyme, phosphofructokinase, and with a series of crystal structures and biochemical studies over a period of 15 years defined the structural mechanism of its cooperativity and allosteric regulation. Following a collaboration with Kiyoshi Nagai in his early work on protein-RNA complexes, he worked on methylmalonyl-CoA mutase (with Peter Leadlay), solving the first structure of an enzyme that uses coenzyme B12, adenosylcobalamin. Since the late 1990s he has worked on the structure and function of proteins involved in vesicle trafficking and endocytosis, with Harvey McMahon and David Owen.
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论文共 36 篇作者统计合作学者相似作者
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biorxiv(2022)
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