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This laboratory studies G protein-coupled receptors of the immune system. These include a large family of chemokine receptors and a smaller group of classical chemoattractant receptors, which together differentially regulate specific leukocyte trafficking in support of innate and adaptive immune responses.
The goal of the lab is to delineate the precise mechanisms by which the receptors relay chemotactic signals to cells and to identify their exact physiologic roles both in immunoregulation and in immunologically mediated disease. The approaches used are to isolate specific chemoattractant receptors by molecular cloning, to examine their signal transduction properties both in model cell systems and in primary cells, and to study their biology in mouse models and, where possible, in patients through direct clinical research.
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论文共 220 篇作者统计合作学者相似作者
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JOURNAL OF CLINICAL PERIODONTOLOGYno. 4 (2024): 464-473
JOURNAL OF IMMUNOLOGYno. 12 (2023): 1913-1924
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Bloodno. 1 (2023): 23-32
Shamik Majumdar,Joseph D. Weaver,Sergio M. Pontejo,Mahnaz Minai,Shalamar Georgia-Clark,Ji-Liang Gao, Xinping Lu, Hongwei Zhang, Nicole Lackemeyer, Tracey Burdette,Reed Johnson,Brian L. Kelsall,
bioRxiv (Cold Spring Harbor Laboratory) (2023)
Vincent Rondeau, Maria Kalogeraki, Lilian Roland, Zeina Abou Nader,Vanessa Gourhand,Amélie Bonaud,Julia P. Lemos,Mélanie Khamyath, Clémentine Moulin,Bérénice Schell,Marc Delord,Ghislain Bidaut,
bioRxiv (Cold Spring Harbor Laboratory) (2023)
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