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Bio
Research Interests
Vaccines, Gene Therapy, Drug Delivery, Liposomes, Biophysics, Protein Microarray, Epidemiology
Our Applied Proteomics Research Laboratory has developed a high throughput protein expression system called PCR Express which can be used to rapidly generate complete proteomes from any sequenced microorganism. The technology allows different genes to be expressed from their PCR products at the rate of hundreds of proteins per week, manually or with the aid of a robotic workstation. The proteomes can be made available in a purified soluble form, on proteome microarray chips, and as arrays of expression ready plasmid clones. At the heart of this technology is an in vivo recombination cloning method that allows PCR fragments to be rapidly inserted into expression plasmids in a high throughput manner. The plasmids can be expressed in an in vitro system, the resulting proteins spotted onto microarray chips, and the chips can be used to monitor antigen specific antibody titers against the arrayed proteins. A paper from our lab describing some aspects of this technology was published in the Journal of Biological Chemistry.
Research Interests
Papers共 426 篇Author StatisticsCo-AuthorSimilar Experts
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Jacqueline Wistuba-Hamprecht,Bernhard Reuter,Rolf Fendel,Stephen L Hoffman,Joseph J Campo,Philip L Felgner,Peter G Kremsner,Benjamin Mordmüller,Nico Pfeifer
PLoS computational biologyno. 6 (2024): e1012131-e1012131
LIFE SCIENCE ALLIANCEno. 3 (2024)
Inayat Bhardwaj,Prince B. Nyarko, Asrar Ba Ashn, Camille Cohen,Sukai Ceesay,Jane Achan,Edgard Dabira, Rike Nakajima,Aarti Jain,Omid Taghavian,Algis Jasinskas,Philip L. Felgner,
medrxiv(2024)
bioRxiv : the preprint server for biology (2024)
Research Square (Research Square) (2023)
Nature Communicationsno. 1 (2023): 1-20
PATHOGENSno. 7 (2023)
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