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When the body encounters invading pathogens, such as bacteria, a series of interactions between host immune cells and pathogen is initiated. These interactions are highly dynamic and involve complex genetic signalling pathways deriving from both the host and the pathogen. White blood cells, or leukocytes, of the host are able to phagocytose (internalise) bacteria and have an artillery of killing mechanisms to disarm the infection.
However some bacteria, such as Mycobacterium tuberculosis, have evolved to survive and proliferate within host immune cells, disarming the leukocytes to make a niche in which to prosper. These types of infection have been historically successfully treated by targeting the bacteria using antibiotics. However, more recently, there has been an alarming rise in strains which are multi-drug resistant. Further understanding of the host response to infection is required to identify genetic targets for much needed future host-targetted therapies.
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论文共 41 篇作者统计合作学者相似作者
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bioRxiv (Cold Spring Harbor Laboratory) (2023)
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Abigail M Elliot,Isabel Ribeiro Bravo,Jeanette Astorga Johansson, Esme Hutton,Richard Cunningham,Henna Myllymaki, Kai Yee Chang,Mariana Beltran,Ross Dobie,Phil Elks, Carsten Gram / G Hansen,Neil Henderson,
biorxiv(2023)
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Principles of Fish Immunologypp.203-227, (2022)
Ffion R Hammond,Amy Lewis,Holly E Anderson, Lewis G Williams,Annemarie H. Meijer,Geert F Wiegertjes,Philip M Elks
biorxiv(2022)
Hannah M Isles,Catherine A Loynes,Sultan Alasmari,Fu Chuen Kon,Katherine M Henry,Anastasia Kadochnikova,Jack Hales,Clare F Muir,Maria-Cristina Keightley,Visakan Kadirkamanathan,Noémie Hamilton, Graham J Lieschke,
semanticscholar(2021)
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