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Having worked out the motivational mechanism for one behavior, the Pfaff lab expanded their focus to ask: Does there exist a form of motivation which helps to initiate all behaviors? The lab formulated the concept of generalized CNS arousal (GA), produced evidence that it exists, and has been working on it in three ways. They started by showing that giant medullary reticular formation neurons foster GA. They are working to differentiate SY5Y cells into dopaminergic neurons, given that dopamine is an essential arousal signal. They will also study arousal effects of noradrenergic neurons, using simple mathematical tools in the data analysis.
Pfaff is also overseeing the publication of the third edition of his textbook Neuroscience in the 21st Century, provided free of charge to medical and grad students and other scholars in economically developing countries.
Pfaff is also overseeing the publication of the third edition of his textbook Neuroscience in the 21st Century, provided free of charge to medical and grad students and other scholars in economically developing countries.
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Ana Ribeiro, Rachel Gabriel, Bernardo Garcia, Casey Cuccio, William Aqeel, Alejandro Moreno, Colby Landeen,Arlene Hurley, Neil Kavey,Donald Pfaff
Origins of Human Socializationpp.59-78, (2021)
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