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Dr. Setlow's laboratory has ongoing multidisciplinary research projects attempting to determine: 1) the mechanisms involved in the extraordinary resistance of spores to heat and oxidizing agents; 2) the mechanism(s) of spore germination and its heterogeneity; and 3) the structure and organization of the inner membrane of spores. Methods used in these projects include: 1) molecular biology to make directed mutants in key spore genes; 2) confocal fluorescence spectroscopy to localize and co-localize proteins in spores; 3) determination of structures of key spore germination and resistance proteins by X-ray crystallography; 4) classical genetics to identify new genes important in aspects of spore germination and resistance; 5) identify new factors important in spore resistance; 6) determine the mechanism(s) whereby moist heat, the most commonly used method to kill spores, actually works to kill spores; and 7) determine factors responsible for the extreme heterogeneity in spore germination such that while most spores in populations germinate within 30 min of addition of a germinant, a small percentage of spores may not germinate for hours or even days.
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Journal of applied microbiologyno. 7 (2024)
Journal of applied microbiologyno. 3 (2023)
Frontiers in Microbiology (2023): 1161604-1161604
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