基本信息
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Bio
We are studying the mechanism of viral membrane fusion and its inhibition by drugs and antibodies. We use the HIV envelope protein (gp120/gp41) as a model system. Some of our studies are aimed at creating an HIV vaccine that elicits antibodies against a transient, but vulnerable, intermediate in the membrane-fusion process, called the pre-hairpin intermediate.
We are also interested in protein surfaces that are referred to as "non-druggable". These surfaces are defined empirically based on failure to identify small, drug-like molecules that bind to them with high affinity and specificity. Some of our efforts are aimed at characterizing select non-druggable targets. We are also developing methods to identify ligands for non-druggable protein surfaces.
We are also interested in protein surfaces that are referred to as "non-druggable". These surfaces are defined empirically based on failure to identify small, drug-like molecules that bind to them with high affinity and specificity. Some of our efforts are aimed at characterizing select non-druggable targets. We are also developing methods to identify ligands for non-druggable protein surfaces.
Research Interests
Papers共 295 篇Author StatisticsCo-AuthorSimilar Experts
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Nature Chemical Biologyno. 8 (2024): 1-10
Science (New York, N.Y.)no. 6704 (2024): 46-53
npj Vaccinesno. 1 (2024): 1-11
bioRxiv : the preprint server for biology (2023)
PROTEIN SCIENCE (2023)
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biorxiv(2023)
Payton Weidenbacher, Sriharshita Musunuri,Abigail E Powell,Shaogeng Tang,Jonathan Do,Mrinmoy Sanyal,Peter S Kim
Nature Biotechnologyno. 2 (2022): 275-283
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Author Statistics
#Papers: 296
#Citation: 37432
H-Index: 89
G-Index: 192
Sociability: 7
Diversity: 3
Activity: 53
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