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Bio
RESEARCH:
General Research Areas: neurodegeneration, anthelmintics, nematicides, drug discovery, pharmacological interactions with amyloids and intrinsically disordered proteins
Dr. Roy has pioneered the use of the nematode C. elegans to discover useful small molecule tools and potential drug leads. He is currently leading projects in the following areas:
Parasitic Prodrugs: Dr. Roy’s group has discovered a suite of small molecules that are bioactivated within nematodes into lethal products. Focusing on ‘nemactivin’, they have shown its bioactivation is restricted to nematodes and that it has real-world utility against plant parasitic nematodes. They are: i) further developing nemactivin as a nematicide with industrial partners; ii) developing additional nematicide prodrugs, and iii) building a system to identify otherwise innocuous small molecules that can be metabolically converted into lethal products within any targeted organism.
Nematicidal Neuromodulators: Dr. Roy’s group has developed a pipeline to identify small molecule disruptors of motor behaviour in nematodes. They discovered a scaffold called ‘nementin’ that induces convulsions, paralysis and death though massive synaptic vesicle release. They are further developing nementin with industrial partners and working to better understand its mechanism of action.
Pharmacological Interactions with Intrinsically Disordered Proteins and Relationships to Neurodegeration: Dr. Roy’s group discovered that select small molecules form crystals within the C. elegans alimentary cuticle. At least two cuticle components are required for this phenomenon; intrinsically disordered proteins (IDPs; see below) and polar lipids. Molecules that are known to prevent human amyloid formation disrupt crystal formation in the IDP-rich cuticle. Dr. Roy’s group is exploiting this system to identify novel small molecules that disrupt amyloid formation and develop them as candidate treatments of amyloid-based diseases such as Alzheimer’s.
General Research Areas: neurodegeneration, anthelmintics, nematicides, drug discovery, pharmacological interactions with amyloids and intrinsically disordered proteins
Dr. Roy has pioneered the use of the nematode C. elegans to discover useful small molecule tools and potential drug leads. He is currently leading projects in the following areas:
Parasitic Prodrugs: Dr. Roy’s group has discovered a suite of small molecules that are bioactivated within nematodes into lethal products. Focusing on ‘nemactivin’, they have shown its bioactivation is restricted to nematodes and that it has real-world utility against plant parasitic nematodes. They are: i) further developing nemactivin as a nematicide with industrial partners; ii) developing additional nematicide prodrugs, and iii) building a system to identify otherwise innocuous small molecules that can be metabolically converted into lethal products within any targeted organism.
Nematicidal Neuromodulators: Dr. Roy’s group has developed a pipeline to identify small molecule disruptors of motor behaviour in nematodes. They discovered a scaffold called ‘nementin’ that induces convulsions, paralysis and death though massive synaptic vesicle release. They are further developing nementin with industrial partners and working to better understand its mechanism of action.
Pharmacological Interactions with Intrinsically Disordered Proteins and Relationships to Neurodegeration: Dr. Roy’s group discovered that select small molecules form crystals within the C. elegans alimentary cuticle. At least two cuticle components are required for this phenomenon; intrinsically disordered proteins (IDPs; see below) and polar lipids. Molecules that are known to prevent human amyloid formation disrupt crystal formation in the IDP-rich cuticle. Dr. Roy’s group is exploiting this system to identify novel small molecules that disrupt amyloid formation and develop them as candidate treatments of amyloid-based diseases such as Alzheimer’s.
Research Interests
Papers共 70 篇Author StatisticsCo-AuthorSimilar Experts
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bioRxiv (Cold Spring Harbor Laboratory) (2023)
Natureno. 7963 (2023): 102-109
Nature Communicationsno. 1 (2022): 5653-13
microPublication biology (2022)
bioRxiv (Cold Spring Harbor Laboratory) (2022)
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