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Bio
The principal area of research focus is the elucidation of the cellular and molecular processes by which cellular stress disrupts embryonic function and the intercellular defense systems that embryos use to limit these effects. Research in the laboratory demonstrated that preimplantation embryonic development is disrupted by exposure to elevated temperature and that embryos acquire resistance to elevated temperature as they proceed through development. It was also shown that embryonic resistance to heat shock is controlled by genetic factors, with embryos from Bos indicus being more resistant to heat shock than embryos from B. taurus. Moreover, embryonic thermotolerance can be enhanced by manipulating heat shock protein synthesis and treatment with the survival factor, insulin-like growth factor-1. My current focus is on understanding the molecular basis for these determinants of thermotolerance with emphasis on the role of apoptosis, heat shock protein synthesis, and free radical metabolism.
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Papers共 262 篇Author StatisticsCo-AuthorSimilar Experts
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Quinn A. Hoorn,Maria B. Rabaglino,Thiago F. Amaral, Tatiane S. Maia,Fahong Yu, John B. Cole,Peter J. Hansen
BIOINFORMATICS ADVANCESno. 1 (2024): vbae036-vbae036
THERIOGENOLOGY (2024): 126-131
Daniella C. Heredia,Federico Tarnonsky, Maria C. Lopez-Duarte, Mauro Venturini, Oscar A. Ojeda,Daniel D. Luchini,Peter J. Hansen,Dean Pringle,Nicolas DiLorenzo,Angela M. Gonella-Diaza
JOURNAL OF ANIMAL SCIENCE (2024): 69-70
Camila J. Cuellar, Gabriel A. Zayas, Thiago F. Amaral, Maura S. McGraw,Fahong Yu,Raluca G. Mateescu,Peter J. Hansen
Veterinary Research Communicationspp.1-5, (2024)
Cecilia C. Constantino Rocha,Ana B. Montevecchio, Mackenzie Mazziotta, Alexandra Bennett, Abdul Waheed, Meghan Campbell,Marcello Rubessa,Rebecca Krisher,Philipe Moriel,Peter J. Hansen,Ricardo Chebel,Mario Binelli
JOURNAL OF ANIMAL SCIENCE (2024): 37-38
Alexandra Bennett,Cecilia C. Constantino Rocha, Abdul Waheed, Morgan Brown,Gabriela Dalmaso De Melo,Rubessa Marcello,Ricardo Chebel,Philipe Moriel,Rebecca Krisher,Ky G. Pohler,Peter J. Hansen,Mario Binelli
Reproduction & fertilityno. 4 (2023): 1-7
REPRODUCTION AND FERTILITYno. 2 (2023)
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