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Human biomaterial is an important resource to translate laboratory findings into clinical applications. Therefore, we established an accredited tissue biobank at the Department of Pathology and Molecular Pathology to provide the research community with tissue samples. The biobank’s activity comprises the organization and coordination of a systematic tissue collection under high quality standards following the swiss ethical and legal guidelines. More than 200 different tissue microarrays were generated and many of them are linked to clinico-pathological data. Frozen biospecimens from 10’000 cancer patients are also available and ideally suited for high through-put technology projects. Moreover, 250 early passage cell cultures from multiple solid cancer types are stored in the tissue biobank and can be used for translational and personalized cancer therapy studies.
Our research is focussing on the evaluation of the relationship between molecular aberrations and prognostic/predictive factors in sporadic renal cell cancer (RCC). As the prognosis of advanced RCC is poor, we are specifically interested in the identification of genetic alterations and pathways leading to tumor recurrence and metastasis after nephrectomy. The molecular characterization and decryption of intra-tumoral heterogeneity is the main challenge and of utmost importance to improve prediction and therapeutic strategies of metastatic RCC.
Human biomaterial is an important resource to translate laboratory findings into clinical applications. Therefore, we established an accredited tissue biobank at the Department of Pathology and Molecular Pathology to provide the research community with tissue samples. The biobank’s activity comprises the organization and coordination of a systematic tissue collection under high quality standards following the swiss ethical and legal guidelines. More than 200 different tissue microarrays were generated and many of them are linked to clinico-pathological data. Frozen biospecimens from 10’000 cancer patients are also available and ideally suited for high through-put technology projects. Moreover, 250 early passage cell cultures from multiple solid cancer types are stored in the tissue biobank and can be used for translational and personalized cancer therapy studies.
Our research is focussing on the evaluation of the relationship between molecular aberrations and prognostic/predictive factors in sporadic renal cell cancer (RCC). As the prognosis of advanced RCC is poor, we are specifically interested in the identification of genetic alterations and pathways leading to tumor recurrence and metastasis after nephrectomy. The molecular characterization and decryption of intra-tumoral heterogeneity is the main challenge and of utmost importance to improve prediction and therapeutic strategies of metastatic RCC.
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Mart van Rijthoven,Simon Obahor, Fabio Pagliarulo,Maries van den Broek,Peter Schraml, Holger Moch,Jeroen van der Laak,Francesco Ciompi,Karina Silina
Communications Medicineno. 1 (2024): 1-14
Stefanie R. Dannenmann,Thomas Hermanns,Ali Bransi, Claudia Matter,Lotta von Boehmer,Stefan Stevanovic,Peter Schraml,Holger Moch,Alexander Knuth,Maries van den Broek
crossref(2023)
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Incno. 8 (2023): 100194-100194
bioRxiv (Cold Spring Harbor Laboratory) (2023)
JOURNAL OF PATHOLOGY CLINICAL RESEARCHno. 4 (2023): 273-284
European urology focusno. 5 (2023): 751-759
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