My research work focuses on therapy development for epidermolysis bullosa using antisense oligonucleotides (AONs). Epidermolysis bullosa (EB, incidence ˜1:10,000) is a group of rare, genetic skin disorders featuring blistering of the skin and mucous membranes after the slightest friction. Currently, there are more than 40 different subtypes of EB recognized that are caused by mutations in genes involved in epidermal keratinocyte adhesion and epidermal-dermal anchorage. 19 genes are known to underlie the different subtypes of EB.