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In the developing vertebrate nervous system oligodendrocytes and Schwann cells not only play a vital role in promoting neuron survival, but they also produce the myelin sheath, which is essential for the normal function of the nervous system, a fact underscored by the debilitating consequences of demyelination in multiple sclerosis in the CNS and in peripheral neuropathies of the Charcot-Marie-Tooth (CMT) type.
The discovery of the Periaxin (Prx) gene and its role in forming the Cajal bands (first described by Santiago Ramon y Cajal) in Schwann cells led to the identification of the cause of a severe demyelinating neuropathy-CMT 4F-in humans. This work also permitted the first experimental proof of the proposal by Huxley and Stämpfli (1949) that internodal distance can regulate nerve conduction velocity.
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Rhys Aled Jones,Chelsea N. Davis, Justyna Nalepa‐Grajcar, Hayley Woodruff,Hefin Wyn Williams,Peter M. Brophy, Emma Jones
Rhys Aled Jones,Gwen Rees,Peter Brophy,Hefin Williams,Manod Williams, Russ Morphew,Chelsea Davis, Serian Evans
Eiry Gwenllian Williams,Hefin Wyn Williams,Peter M. Brophy, Serian R. Evans, Heather McCalman,Rhys Aled Jones
animalno. 6 (2024): 101156-101156
Routledge eBookspp.197-212, (2023)
Journal of the peripheral nervous system : JPNS (2023): S3-S11
Clare F Collett,Helen C Phillips,Maggie Fisher, Sian Smith,Caroline Fenn, Phil Goodwin,Russell M Morphew,Peter M Brophy
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