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My research career has been focussed on understanding integrated systems-level responses – particularly cardiorespiratory and metabolic responses – to hypoxia, to exercise and, more recently, to variations in iron status. After completing my doctorate in physiology and a qualification in clinical medicine, I joined the Department in 1985 where I have worked ever since.
During my early career I developed the technique of dynamic end-tidal forcing, and built upon that research by developing a chamber in which the levels of carbon dioxide and oxygen in the arterial blood could be kept constant in humans for days at a time. This allowed me to study acclimatization to hypoxia, and in particular show that it did not require an associated respiratory alkalosis to develop – thus discrediting an almost century-old hypothesis.
During my early career I developed the technique of dynamic end-tidal forcing, and built upon that research by developing a chamber in which the levels of carbon dioxide and oxygen in the arterial blood could be kept constant in humans for days at a time. This allowed me to study acclimatization to hypoxia, and in particular show that it did not require an associated respiratory alkalosis to develop – thus discrediting an almost century-old hypothesis.
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Dominic Sandhu, Jennifer L Redmond,Nicholas M J Smith,Christopher Short,Clare J Saunders,John H Couper,Christopher J Fullerton,Graham Richmond,Nick P Talbot, Jane C Davies,Grant A D Ritchie,Peter A Robbins
Journal of applied physiology (Bethesda, Md. : 1985) (2023)
Christopher Short,D. P. S. Sandhu,Nick Smith, M. Abkir, S. Pinnell,Clare Saunders, John Redmond, Jennifer Couper, Christina Fullerton,Graham Richmond,Nick P. Talbot,Jane C. Davies,
Journal of Cystic Fibrosis (2023): S124-S124
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