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Bio
Colman's research interests are in structural biology, especially of human B-cell lymphoma 2 (BCL-2). Colman determined the three-dimensional structure of the influenza virus neuraminidase and, in one of the earliest cases of structure-based drug design, discovered zanamivir, the first-in-class neuraminidase inhibitor for influenza. His subsequent structural studies on resistance to this drug class suggested how to design drugs against moving targets. His discoveries underpin drug stockpiling for pandemic preparedness. He has made seminal contributions to structural studies of antibodies and antibody-antigen complexes. Recent[when? work on apoptosis solves the long-standing problem of how pro-apoptotic Bax changes conformation to dimerise and then oligomerise and permeabilise the mitochondrial membrane, an essential step in the intrinsic cell-death pathway.
Research Interests
Papers共 599 篇Author StatisticsCo-AuthorSimilar Experts
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The Journal of clinical endocrinology and metabolism (2024)
DIABETES TECHNOLOGY & THERAPEUTICSno. 5 (2024): 335-340
INTERNAL MEDICINE JOURNALno. 1 (2024): 121-128
Michelle S Miller,Angus D Cowan,Jason M Brouwer, Sean T Smyth,Liuyu Peng,Ahmad Z Wardak,Rachel T Uren,Cindy Luo,Michael J Roy,Sayali Shah, Ziwen Tan,Gavin E Reid,
The FEBS journalno. 11 (2024): 2335-2353
Rahul D Barmanray,Mervyn Kyi,Peter G Colman,Lois Rowan, Mayurapriya Raviskanthan, Lucy Collins, Laura Donaldson, Stephanie Montalto,Joshua Tsan, Emily Sun, Minh Le,Leon J Worth,
Diabetes careno. 6 (2024): 948-955
DIABETES TECHNOLOGY & THERAPEUTICSno. 2 (2024): 87-94
Diabetic medicine : a journal of the British Diabetic Associationno. 11 (2023)
Diabetic medicine : a journal of the British Diabetic Associationno. 4 (2023): e15264-e15264
Journal of sleep researchno. 4 (2023): e14106-e14106
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Author Statistics
#Papers: 548
#Citation: 36503
H-Index: 92
G-Index: 183
Sociability: 8
Diversity: 1
Activity: 4
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