The Shi lab integrates both academic and industrial expertise for basic and translational research. Our research focuses on flaviviruses that cause significant human diseases, such as dengue, West Nile, and Japanese encephalitis viruses. Despite their global public health burden, there is no clinically approved therapy for flavivirus infection. To address this huge unmet medical need, we take a multidisciplinary approach (i) to study the molecular mechanism of viral replication and (ii) to translate the knowledge into antiviral/vaccine products. Many of our projects are highly collaborative with both academic and pharmaceutical partners around the world. We also aspire to apply the knowledge achieved from the flavivirus research to drug discovery and vaccine development for other viral pathogens.