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个人简介
Pedro Borralho received his degree in Biotechnology Engineering in 2004. He performs colon cancer research since 2005. His PhD studies were performed at the Faculty of Pharmacy of the University of Lisbon (FFUL), and at the University of Minnesota Medical School, Gastroenterology, Hepatology and Nutrition Division, having received his PhD in 2009, from the University of Lisbon. From 2010 to 2011 he developed post-doctoral studies at Centro de Investigação em Patobiologia Experimental, Instituto Português de Oncologia de Lisboa Francisco Gentil (IPOLFG), and at Research Institute for Medicines and Pharmaceutical Sciences (iMed.UL), FFUL. He was Assistant Investigator at FFUL (2012-2015). Currently he is Invited Assistant Professor at Faculty of Pharmacy, University of Lisbon and Cell Function responsible at iMed.ULisboa since Dec 2013. During his graduate work, he explored 5-fluorouracil molecular cell death pathways. He also explored miR-143 biological role, showing that its over-expression reduces colon cancer cell viability and sensitizes to 5-FU-induced apoptosis, via ERK5/NF-kB signaling pathway(s). He has also been actively involved in identifying miRNA expression profiles in colon cancer, contributing to added knowledge of microRNAs aberrantly expressed in colon cancer progression. These results are part of ongoing collaborations with Professor Clifford Steer, University of Minnesota, USA, and Dr. Stephen Thibodeau, Mayo Clinic, USA. These studies are currently being expanded, by evaluating miRNAs differentially expressed in colon cancer, exploring their biological roles in colon cancer progression and chemotherapy and targeted therapy response, dissecting cell death, proliferation and survival pathways. He is exloring the biological relevance of ERK5 and its relevance as a therapeutic target in colon cancer. He is also investigating miRNA mimetics and inhibitors as therapeutic strategies for colon cancer and other human malignancies. In addition, he is also interested in the screening and evaluation of anticancer/biological activity of novel synthesis and natural compounds to discover putative novel anticancer & other therapeutic agents.
研究兴趣
论文共 96 篇作者统计合作学者相似作者
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Ana Peixoto,Luís Cirnes, Ana Luísa Carvalho, Maria João Andrade,Maria José Brito,Paula Borralho,Nuno Coimbra,Pedro M Borralho, Ana Sofia Carneiro,Lisandra Castro,Lurdes Correia,Maria Rita Dionísio,
Frontiers in molecular biosciences (2024): 1298522-1298522
Ana Peixoto,Luís Cirnes, Ana Luísa Carvalho, Maria João Andrade,Maria José Brito,Paula Borralho,Paula Borralho,Nuno Coimbra,Pedro M. Borralho, Ana Sofia Carneiro,Lisandra Castro,Lurdes Correia,
Ana Peixoto,Luís Cirnes, Ana Luísa Carvalho, Maria João Andrade,Maria José Brito,Paula Borralho,Pedro M. Borralho, Ana Sofia Carneiro,Lisandra Castro,Lurdes Correia,Maria Rita Dionísio, Carlos Faria,
Ana Peixoto,Luís Cirnes, Ana Luísa Carvalho, Maria João Andrade,Maria José Brito,Paula Borralho,Nuno Coimbra,Pedro M Borralho, Ana Sofia Carneiro,Lisandra Castro,Lurdes Correia,Maria Rita Dionísio,
Frontiers in molecular biosciences (2023): 1082915-1082915
FRONTIERS IN MOLECULAR BIOSCIENCES (2023)
Cell Death Discoveryno. 1 (2019): 1-13
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