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个人简介
Research Interests
Characterization and therapy of canine and feline genetic disease for the development of treatments and DNA-based genetic tests and as models of human genetic disease.
Key words: Dog, cat, molecular genetics, gene mapping, complex inheritance.
Description of Research
Research activities focus on the characterization of inherited diseases in dogs and cats, with goals of developing DNA-based tests that can be used to eliminate diseases from companion animals by selective breeding, and to develop and test therapeutic approaches for treatment of genetic diseases in both man and animals. In collaboration with other colleagues at the School of Veterinary Medicine, various heritable diseases are currently under study, including multiple forms of congenital heart disease, dilated cardiomyopathy, multiple forms of cystinuria, deafness, diabetes, protein losing nephropathy, and protein losing enteropathy.
DNA-based Genetic Tests for Dogs
In the course of our research, we have developed genetic tests for various canine diseases, including juvenile dilated cardiomyopathy (JDCM) in Portuguese water dogs, Protein Losing Nephropathy (PLN) in soft-coated wheaten terriers, and various forms of cystinuria in Newfoundlands, Labrador retrievers, Mastiffs (and related breeds). Contact JDCMtest@vet.upenn.edu and CystinuriaDNAtest@gmail.com for further information and instructions.
Rotation Projects for 2012-2013
Please see Dr. Henthorn.
Characterization and therapy of canine and feline genetic disease for the development of treatments and DNA-based genetic tests and as models of human genetic disease.
Key words: Dog, cat, molecular genetics, gene mapping, complex inheritance.
Description of Research
Research activities focus on the characterization of inherited diseases in dogs and cats, with goals of developing DNA-based tests that can be used to eliminate diseases from companion animals by selective breeding, and to develop and test therapeutic approaches for treatment of genetic diseases in both man and animals. In collaboration with other colleagues at the School of Veterinary Medicine, various heritable diseases are currently under study, including multiple forms of congenital heart disease, dilated cardiomyopathy, multiple forms of cystinuria, deafness, diabetes, protein losing nephropathy, and protein losing enteropathy.
DNA-based Genetic Tests for Dogs
In the course of our research, we have developed genetic tests for various canine diseases, including juvenile dilated cardiomyopathy (JDCM) in Portuguese water dogs, Protein Losing Nephropathy (PLN) in soft-coated wheaten terriers, and various forms of cystinuria in Newfoundlands, Labrador retrievers, Mastiffs (and related breeds). Contact JDCMtest@vet.upenn.edu and CystinuriaDNAtest@gmail.com for further information and instructions.
Rotation Projects for 2012-2013
Please see Dr. Henthorn.
研究兴趣
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PloS oneno. 9 (2020): e0239542-e0239542
Canine Medicine and Geneticsno. 1 (2020): 1-6
Margret L Casal,Julie B Engiles,Maja Zakošek Pipan, Asaf Berkowitz,Yael Porat-Mosenco,Wilfried Mai, Kirsten Wurzburg,Mei-Qi Xu,Robyn Allen,Patricia A ODonnell,Paula S Henthorn,Keith Thompson,
PLOS ONEno. 1 (2017): 0170708-0170708
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