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I am motivated by understanding the mechanisms that govern glycan expression and recognition and its impact in human biology and disease. I am an expert in Glycobiology and its interface with Immunology and Oncology. I am highly committed to translate research finding into innovative treatments, centered on patient needs. I am currently focused on three interconnected areas: i) mechanisms driving the expression of aberrant sialylated short O-glycans in cancers and its implications for tumour immunity and progression. ii) the role of sialylated glycans in the expression of immunomodulatory molecules and its role in curbing immune responses. iii) the impact of Congenital defects of glycosylation (CDG) in immune response and susceptibility to infection.
I am currently an Associate Professor at Faculdade de Ciências e Tecnologia/ Universidade NOVA de Lisboa (FCT-NOVA) and principal investigator of the Glycoimmunology Group at UCIBIO research unit. In the past few years, our efforts were fruitful in several ways: (A) We published 101 research papers and four patents (as PI) describing various roles of glycans, in several top-ranked journals (e.g. BBA, Molecular Oncology); a featured immunology article (doi: 10.4049/jimmunol.1890012); 11 invited reviews (highly cited doi: 10.3390/ijms19051304), and clinical guidelines (doi: 10.1002/jimd.12024.) (B) Me (plenary, keynote and invited speaker, moderator, chair) and my students have presented unpublished data in several national and international conferences (e.g. EuroCarb, SSIEM, AAI, PEGS). Noteworthy, my students' work was selected for several prestigious meetings. (C) I secured almost 4.5 million EUR for research plus 1.4 million EUR to spin-off our technology, including prestigious EU grants (Twinning, MSCA, EJPRD), prizes and research agreements with biopharmaceuticals. Important, my students and researchers secured individual fellowships. (D) I belonged to the Scientific council of COST, and I am currently part of the IAB of the Slovak Academy of Sciences and RD-Portugal, editorial board of Scientific Report, guest editor of Cancers and reviewer of several journals and international research applications. (E) I organize international courses on Glycosciences as e-learning and Workshops and organized several other meetings. (F) I co-founded the CDG&Allies-PPAIN, a unique patient-centric network, that gathers professionals and patient associations worldwide to foster research and awareness on rare diseases of glycosylation. This network joins almost 100 professionals and has produced several scientific reviews, medical guidelines, and lay language documents for society. (G) In 2019, I co-founded the spin-off CellmAbs, a biopharmaceutical developing immuno-oncology agents for tumour associated glycans. CellmAbs was elected to the top 30 by Biotecnika and featured by Labiotech and BIO-Europe 2020.
My research is highly multidisciplinary and uses cutting edge methodologies as in vitro and in vivo assays, omics, bioinformatic tools and patient-centric approaches with the ultimate goal of translating research findings into patient benefits.
Research Interests
Papers共 144 篇Author StatisticsCo-AuthorSimilar Experts
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Scientific Reportsno. 1 (2024): 1205-1205
Carlota Pascoal,Rita Francisco, Patricia Mexia, Beatriz Luis Pereira,Pedro Granjo,Helena Coelho, Mariana Barbosa,Vanessa dos Reis Ferreira,Paula Alexandra Videira
FRONTIERS IN IMMUNOLOGY (2024): 1350101-1350101
MOLECULESno. 5 (2024): 1129
Journal of Molecular Medicineno. 3 (2024): 365-377
Marta Falcão,Mariateresa Allocca,Ana Sofia Rodrigues,Pedro Granjo,Rita Francisco,Carlota Pascoal,Maria Grazia Rossi,Dorinda Marques-da-Silva,Salvador C M Magrinho,Jaak Jaeken, Larisa Aragon Castro,Cláudia de Freitas,
Orphanet journal of rare diseasesno. 1 (2023): 1-9
Medical Sciences Forumno. 1 (2022): 7
BiTaP 2022 (2022)
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Author Statistics
#Papers: 143
#Citation: 2894
H-Index: 30
G-Index: 48
Sociability: 7
Diversity: 4
Activity: 27
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