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My laboratory uses molecular biological and genomic approaches to study hormonal regulation of transcription, particularly thyroid hormone (TH). We study whether epigenetic changes such as DNA methylation and histone modifications play a role in positive and negative regulation of transcription, endocrine tumors which hyper-secrete hormones, long-term suppression of negative feedback by TH, and hormone-responsiveness during aging. He also examines the potential beneficial effects and mechanisms of TH on non-alcoholic fatty liver disease (NAFLD), a common complication of obesity and diabetes. My laboratory’s recent discovery that TH as well as other hormones and compounds can induce autophagy coupled with beta oxidation of fatty acid has provided novel potential therapeutic strategies for the condition. I will initiate clinical studies examining whether TH can ameliorate NAFLD and glucose control in diabetic patients.
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Madhulika Tripathi,Karine Gauthier,Reddemma Sandireddy,Jin Zhou, Priyanka Gupta, Suganya Sakthivel, Nah Jiemin, Kabilesh Arul,Keziah Tikno,Sung-Hee Park, Lijin Wang,Lena Ho,
bioRxiv : the preprint server for biology (2024)
Bio-protocolno. 13 (2023): e4773-e4773
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JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISMno. 3 (2023): E36-E37
bioRxiv (2021)
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