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Bio
Englund’s career in the Department of Biological Chemistry at the Johns Hopkins University School of Medicine spanned more than 40 years, during which he published over 160 research papers and mentored scores of research trainees in his laboratory.
He is best known for studying the structure and mechanics of genetic material in parasitic organisms called trypanosomes, which cause African sleeping sickness. The potentially lethal disease is spread by the tsetse fly in sub-Saharan parts of Africa and gets its name from disrupting victims’ sleep patterns.
Among his research discoveries, Englund found that trypanosomes make fatty acids in a way that is unique to the organism. The discovery is important because sugars and fats make up substances called GPI anchors, which are found on cell surfaces and act like anchors for proteins and other molecules important to the cell. In trypanosomes, GPI-anchored proteins switch periodically to evade attack by the host’s immune system.
Research Interests
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