Dr Nathan has a specialist interest in the treatment of renal cell carcinoma (kidney cancer) and melanoma (both uveal and cutaneous). He also has an interest in Merkel Cell Carcinoma.

He is the first author of the UK guidelines for the systemic treatment of renal cell carcinoma, a member of the National Cancer Research Institute groups for both renal carcinoma and melanoma and is secretary of the UK Melanoma Study Group. He also is a member of the panel currently reviewing the national melanoma guidelines.