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个人简介
Associate Professor Paul Neeson completed a PhD at the University of Melbourne (Pathology), before doing a post-doc in the Paterson lab (University of Pennsylvania) where he worked on B-cell lymphoma vaccines. He returned to Melbourne and established the human immunology translational lab (HITRL) in Cancer Immunology Research at the Peter MacCallum Cancer Centre. The lab’s original focus was in haematological cancers, examining responses to novel immunotherapy combinations. Along with the increasing clinical interest in Immuno-Oncology, his lab now also examines the immune context of solid tumours and patient responses to checkpoint inhibitor or chimeric antigen receptor T cell therapy.
Recent immunotherapy trials have shown dramatic responses in patients with a wide range of cancer sub-types. However, predicting which patients will respond to immunotherapy, and what type of immunotherapy is appropriate has proven difficult. To address these issues, we have developed a range of technologies to explore the immune context of human cancer including multiplex immuno-histochemistry, immune gene expression profile and immune signal network analysis on primary or metastatic tumour FFPE sections. We have also developed a TIL (tumour-infiltrating lymphocyte) program to explore the immune context by mass cytometry in fresh tumour samples
The Neeson Laboratory explores the human immune system responses to tumour development and to immunotherapy. We do this using patient samples from cohort studies or clinical trials. Having made observations in these samples, we then explore immunotherapy drug combination mechanism of action in model systems to provide new information for rational use of these drugs in the clinic.
研究兴趣
论文共 252 篇作者统计合作学者相似作者
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EUROPEAN UROLOGYno. 3 (2024): 217-226
Jack D. Chan, Christina M. Scheffler,Isabelle Munoz,Kevin Sek,Joel N. Lee,Yu-Kuan Huang, Kah Min Yap,Nicole Y. L. Saw,Jasmine Li,Amanda X. Y. Chen,Cheok Weng Chan,Emily B. Derrick,
Jasper de Boer, Rebecca Barnett,Anthony Cardin,Michelle Cimoli, Lauren Davies,Clare Delany,Benjamin J. Dixon,Sue M. Evans,Michael W. Findlay,Carly Fox,Maria Ftanou, Christopher D. Hart,
CANCERSno. 7 (2024): 1277
crossref(2023)
Nature cancerno. 4 (2023): 444-446
Ran Li,Sneha Sant,Emmaline Brown,Franco Caramia,Bronte Nikolic,Kylie Clarke,Ann Byrne, Luis E. Lara Gonzalez,Peter Savas,Stephen J. Luen,Zhi Ling Teo,Balaji Virassamy,
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTEno. 7 (2023): 805-814
crossref(2023)
Science Translational Medicineno. 690 (2023)
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