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个人简介
With my close colleagues Dr. Bert van der Zaal, Dr. Paul van Heusden and Dr. Sylvia de Pater and the help of many postdocs, PhD students, MSc and BSc students I have been studying Agrobacterium and its applications already for many years. Results have often been surprising and have taught us about the ingenious ways this bacterium manipulates host cells. On the basis of this knowledge we have built tools that are helpful for the study and genetic modification of (cop) plants, such as the binary vector system, which was developed in our group and which is used world-wide for the construction of transgenic plants. We have more recently discovered that Agrobacterium cannot only be used for the transformation of plants, but also of yeasts and fungi. Therefore, the bacterium is now also a favorite vector for the genetic modification of many fungi and mushrooms. At the same time it allowed us to use the model yeast Saccharomyces cerevisiae in our investigations of the molecular mechanism of Agrobacterium-mediated transformation (AMT). Our discovery that besides DNA molecules also several (effector) virulence proteins are separately and independently of the T-DNA introduced into host cells during infection has led us to research aimed to develop methodology for protein therapy.
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