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个人简介
I am Senior Director, Computational Genomics at Vertex Pharmaceuticals, with a broad background in structural biology, bioinformatics and human genetics. At Vertex, I lead a top-tier Computational Genomics team, collaborating across our three R&D sites in Boston, San Diego, and Oxford. We use a combination of genomics and bioinformatics (i) to identify and validate potentially novel drug targets, (ii) to delineate patient responder populations and (iii) to propose early response biomarkers across our drug discovery portfolio.
Previously, I led academic research groups at the Brigham and Women's Hospital, Harvard Medical School, and University Medical Center Utrecht, studying human genome sequence variation (e.g. Genome of the Netherlands Project) and the genetic basis of human disease (e.g. ischemic stroke, HIV control and many other immune-mediated disorders). In particular, we have developed novel methods for interrogating the major histocompatibility complex. I have participated in several collaborative consortia, published 250+ peer-reviewed papers, and mentored 10+ PhD students and postdoctoral fellows.
研究兴趣
论文共 314 篇作者统计合作学者相似作者
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biorxiv(2023)
Sander W van der Laan,Marten A Siemelink,Saskia Haitjema,Hassan Foroughi Asl,Ljubica Perisic,Michal Mokry,Jessica van Setten,Rainer Malik, Martin Dichgans,Bradford B Worrall,Nilesh J Samani, Heribert Schunkert,
Seamus C Harrison,Michael V Holmes,Stephen Burgess, Folkert W Asselbergs,Gregory T Jones,Annette F Baas, F N van 't Hof,Paul I W de Bakker,Jan D Blankensteijn,Janet T Powell,Athanasios Saratzis,Gert J de Borst,
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