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Bio
Plant cells change their cell wall dramatically during growth and differentiation. The Dupree Group is focused on understanding the biosynthesis and function of polysaccharide components of the plant cell wall. Despite these polysaccharides being some of the most abundant on Earth, and them having enormous nutritional, agricultural, and industrial importance, surprisingly little is known about the genes and enzymes that carry out their synthesis. The polysaccharides are synthesised by an amazing variety of enzymes in the Golgi apparatus. Crucial players in polysaccharide synthesis are sugar nucleotide transporters and glycosyltransferases in the Golgi lumen.
The major focus of our research is the biosynthesis of xylans and glucomannans in different plant species. We are studying the function of Golgi biosynthetic proteins using functional genomics. To identify candidate genes we use a combination of bioinformatic and proteomic approaches. By studying the composition of the extracellular matrix and the structural changes in specific polysaccharide components of mutant Arabidopsis plants, we are bit by bit deciphering the role of the individual proteins. Biochemical assays allow us to investigate the activities of these proteins, complementing our understanding of gene function.
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Papers共 289 篇Author StatisticsCo-AuthorSimilar Experts
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Li Yu,Louis F L Wilson, Oliver M Terrett, Joel Wurman-Rodrich,Jan J Łyczakowski, Xiaolan Yu, Kristian B R M Krogh,Paul Dupree
The New phytologist (2024)
PLANT BIOTECHNOLOGY JOURNALno. 3 (2024): 587-601
Li Yu,Louis F.L. Wilson,Oliver M. Terrett, Joel Wurman-Rodrich,Jan J. Lyczakowski,Xiaolan Yu,Kristian B.R.M. Krogh,Paul Dupree
biorxiv(2024)
The Cell Surface (2024): 100121-100121
Zenodo (CERN European Organization for Nuclear Research) (2023)
Communications biologyno. 1 (2023): 662-3
Communications Biologyno. 1 (2023)
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