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Understanding how the cardiovascular system develops and maintains its function is critical. Cardiac disease is the leading cause of mortality in adults and the primary cause for morbidity. Furthermore, congenital heart disease affects one per cent of newborns. Recent research showed that epigenetic mechanisms like histone methylation operating very early during cardiovascular progenitor development might not only regulate aspects of cell differentiation and morphogenesis, but are also required for long-term cardiac homeostasis and response to pathologic stimuli in the postnatal life. This stresses the relevance of uncovering the functions of histone methylation and other epigenetic processes in cardiovascular development and maintenance to act effectively against congenital and postnatal disease.
Dr. Delgado-Olguin’s laboratory uses in vivo and in vitro approaches to uncover the mechanistic involvement of several histone modifiers in cardiovascular development and maintenance. We use a variety of approaches ranging from analyzing the cardiac and vascular morphology in mutant models, to uncovering the cellular and molecular events controlling cardiovascular differentiation, organogenesis and maintenance.
Dr. Delgado-Olguin’s laboratory uses in vivo and in vitro approaches to uncover the mechanistic involvement of several histone modifiers in cardiovascular development and maintenance. We use a variety of approaches ranging from analyzing the cardiac and vascular morphology in mutant models, to uncovering the cellular and molecular events controlling cardiovascular differentiation, organogenesis and maintenance.
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论文共 62 篇作者统计合作学者相似作者
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Lijun Chi,Dorothy Lee, Sharon Shui Yee Leung,Guanlan Hu,Bijun Wen,Paul Delgado-Olguı́n,Miluska Vissa,Ren Li,John H. Brumell,Peter Kim,Robert Bandsma
Research Square (Research Square) (2023)
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Cellular and molecular life sciences : CMLSno. 7 (2023): 183-20
Molecular therapy. Methods & clinical development (2023): 246-258
BMC Genomicsno. 1 (2023): 709-709
Karen Aitken,Priyank Yadav,Martin Sidler,Thenuka Thanabalasingam, Tabina Ahmed,Prateek Aggarwal, Shing Tai Yip, Nefateri Jeffrey,Jia-Xin Jiang, Aliza Siebenaller,Chris Sotiropoulos,Ryan Huang,
PLOS ONEno. 7 (2023): e0287205-e0287205
Sepideh Sheybani-Deloui, Leo Xu, Lijuan Hu, Qiongjing Yuan,Joe Eun Son,Kyoung-Han Kim,Weifan Liu,Rong Mo,Xiaoyun Zhang,Lijun Chi,Paul Delgado Olguin,Chi-Chung Hui
biorxiv(2022)
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