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We are studying the novel, RNA-based pathways and virus-host interactions underlying replication, gene expression and evolution by positive-strand RNA viruses, the largest class of viruses. Positive strand RNA viruses include many important human pathogens such as hepatitis C virus, which chronically infects nearly 3% of the world population, causing progressive liver damage and liver cancer, and the new SARS coronavirus. We are also studying selected replication processes of a reverse-transcribing virus, hepatitis B virus, which is also a major human tumor virus. Our studies integrate molecular genetics, genomics, biochemistry and cell biology to address fundamental questions in virus replication and virus-cell interactions.
Viruses are divided into six distinct classes differing in the type of nucleic acid in the virus particle and its replication pathways. Recently, we discovered multiple, detailed structural and functional parallels among the replication complexes of three of these six virus classes: positive-strand RNA viruses, retroviruses and dsRNA viruses. These results imply a significant functional and evolutionary unification within virology, and have opened the door to many exciting new experimental questions and approaches that we are now pursuing.
We also have identified the first higher eukaryotic viruses that can direct genome replication, gene expression and virion assembly in the genetically tractable yeastSaccharomyces cerevisiae. Using yeast genetics and genomics, we are identifying a growing number of host genes required for viral RNA replication and are studying how these function with virus-encoded helicase- and polymerase-like replication factors and diverse cis-acting viral RNA signals to direct assembly and function of the membrane-bound viral genome replication complexes and other processes.
Research Interests
Papers共 238 篇Author StatisticsCo-AuthorSimilar Experts
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mBiono. 6 (2024)
Trends in Geneticsno. 8 (2024): 681-693
bioRxiv : the preprint server for biology (2024)
crossref(2023)
Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canadano. 29 Suppl 1 (2023): 904-905
crossref(2023)
PLoS pathogensno. 7 (2023): e1011492-e1011492
Roma Broadberry,Hong Zhan, Nurrudin Unchwaniwala,Andrea Rebolledo-Viveros,Mark Horswill, Johnathan Meyers,Johan den Boon,Paul Ahlquist, Tim Grant
Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canadano. Supplement_1 (2023): 936-936
OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information) (2022)
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Author Statistics
#Papers: 236
#Citation: 19258
H-Index: 80
G-Index: 136
Sociability: 6
Diversity: 3
Activity: 22
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