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Genomic and Epigenomic Heterogeneity of Stomach Cancer :
Our research focuses on (epi)genomic strategies to unlock the molecular and clinical diversity of gastric cancer (aka stomach cancer) and other Asian-endemic cancers. Understanding how individual gastric tumors vary in their molecular aberrations may allow us to refine therapies for different subgroups of patients displaying distinct patterns of disease aggressiveness and treatment response. Our group has made significant contributions to the gastric cancer field, including one of the earliest transcriptional profiling studies of GC (Tay et al, 2003) which led to an international industry-sponsored multi-centre clinical trial (Tan et al., 2011). We have identified recurrent fusion genes in GC (Palanisamy et al., 2010 in collaboration with Arul Chinnaiyan; Tao et al., 2011), new tumor suppressor genes (Zang et al., 2012), somatic copy number alterations (Deng et al., 2012) and epigenetic alterations in GC (Zouridis et al., 2012; Qamra et al., 2017). Our group is a member of the Singapore Gastric Cancer Consortium, which is also working on strategies for early detection of gastric cancer (Huang et al., 2018).
In collaboration with Prof Teh Bin Tean and A/Prof Steve Rozen, we have also extended our work to other Asian-endemic cancers such as biliary tract cancers (Ong et al., 2012; Chan-on et al., 2013; Jusukul et al., 2017), breast tumors (Lim et al., 2014; Tan et al., 2015) and urogenital malignancies (Poon et al., 2013; Yao et al., 2017), as well as selected flora and fauna in South East Asia (Teh et al., 2017).
Our research focuses on (epi)genomic strategies to unlock the molecular and clinical diversity of gastric cancer (aka stomach cancer) and other Asian-endemic cancers. Understanding how individual gastric tumors vary in their molecular aberrations may allow us to refine therapies for different subgroups of patients displaying distinct patterns of disease aggressiveness and treatment response. Our group has made significant contributions to the gastric cancer field, including one of the earliest transcriptional profiling studies of GC (Tay et al, 2003) which led to an international industry-sponsored multi-centre clinical trial (Tan et al., 2011). We have identified recurrent fusion genes in GC (Palanisamy et al., 2010 in collaboration with Arul Chinnaiyan; Tao et al., 2011), new tumor suppressor genes (Zang et al., 2012), somatic copy number alterations (Deng et al., 2012) and epigenetic alterations in GC (Zouridis et al., 2012; Qamra et al., 2017). Our group is a member of the Singapore Gastric Cancer Consortium, which is also working on strategies for early detection of gastric cancer (Huang et al., 2018).
In collaboration with Prof Teh Bin Tean and A/Prof Steve Rozen, we have also extended our work to other Asian-endemic cancers such as biliary tract cancers (Ong et al., 2012; Chan-on et al., 2013; Jusukul et al., 2017), breast tumors (Lim et al., 2014; Tan et al., 2015) and urogenital malignancies (Poon et al., 2013; Yao et al., 2017), as well as selected flora and fauna in South East Asia (Teh et al., 2017).
Research Interests
Papers共 263 篇Author StatisticsCo-AuthorSimilar Experts
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biorxiv(2024)
CELL HOST & MICROBEno. 3 (2024): 291-293
GUTno. 1 (2024): 1-2
CANCER RESEARCHno. 7 (2023)
crossref(2023)
Nicolas Bertin,Joanna H.J. Tan,Zhihui Li,Mar Gonzàlez-Porta,Ramesh Rajaby, Rodrigo Jiménez,Weng Khong Lim, Yuying Tan,Roy Tang Yi Teo,Maxime Hebrard, Jack Ling Ow,Shimin Ang,
Research Square (Research Square) (2023)
Nature cell biologyno. 5 (2023): 765-777
Natureno. 7948 (2023): E37-E37
crossref(2023)
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