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Bio
P. Renard is one the 6 PI of the Research Unit in Cell Biology (URBC), in the University of Namur.
The URBC gathers several interdisciplinary research teams organized around different research topics. The URBC has a very long experience in the comprehension of the pathological processes related to the pathology at the cellular and transduction level. The lab is composed of about 50 researchers and technicians working in the field of molecular and cellular biology. The fundamental research performed in the URBC aims to understand cellular responses to different stresses such as mitochondrial stress (P. Renard and T. Arnould), atherogenic molecules (M. Raes), hypoxia (C. Michiels), UV exposure (F. Chainiaux).
The URBC is specialised in signal transduction studies, especially at the transcription factor level : the quantitative analysis of more than 30 transcription factors is conducted with a colorimetric DNA-binding assay developed in this lab. Beside, the laboratory masters general techniques both in the domains of molecular biology, of biochemistry and cell biology such as the manipulation of cells, proteins and genomes, like cloning, sequences analyses, gene expression, and reporter genes. These manipulations are routinely performed thanks to leading edge facilities and performing technologies: FPLC, real time PCR (including for microfluidic cards : Applied Biosystems 7900 HT), confocal microscopy. In addition, the URBC has experience in comparative proteomic analysis by 2D-DIGE, and in protein identification by mass spectrometry. It possesses fully equipped proteomic platform and mass spectrometer (MaXis, Bruker) for protein identification.
P. Renard develops two main research axes :
- Study of cell responses to mitochondrial dysfunction (in close collaboration with Prof. T. Arnould)
- Development of original methods to study transcription factors. An ELISA-like assay for the DNA-binding activity of transcription factors was developed, patented and commercialised under by Active Motif under the TransAM trade mark. More recently, an original and powerful method to identify the transcription factors captured by DNA-affinity chromatography by a long (300 bp) regulatory DNA sequence was optimised (ref: Tacheny et al, 2012, Nuc. Acids Res.
Research Interests
Papers共 69 篇Author StatisticsCo-AuthorSimilar Experts
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ACS OMEGAno. 6 (2024): 6505-6526
Giel Schevenels,Pauline Cabochette,Michelle America, Arnaud Vandenborne, Line De Grande,Stefan Guenther,Liqun He,Marc Dieu, Basile Christou,Marjorie Vermeersch,Raoul F V Germano,David Perez-Morga,
Natureno. 8009 (2024): 863-871
Sébastien Meurant, Ilario Amato,Lorris Mauclet,Marc Dieu, Arnaud Chevrollier, Benjamin Ledoux,Marino Caruso, Guy Lenaers,Thierry Arnould,Patricia Renard
biorxiv(2024)
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