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个人简介
My career has been dedicated to research on the genetics of cancer, with emphasis on inherited endocrine tumors and discovery of cancer susceptibility genes (including PTEN, SDHB, KIF1B, EPAS1/HIF2A, TMEM127, etc). This work has had both translational and biological impact. On the translational level, our studies helped define paradigms for genetic testing, patient surveillance, and innovative therapeutic modeling, especially in the area of pheochromocytomas and paragangliomas. Our integrative genomics and signal transduction work uncovered links between energy metabolism, hypoxia, endosome/lysosomal signals and cancer susceptibility. In parallel to the ongoing gene discovery efforts through our patient sample repository (NCT03160274), current lines of investigation in my laboratory explore: a) the function of transmembrane protein TMEM127 tumor suppressor as a nutrient responsive lysosomal component and regulator of insulin sensitivity in vivo, b) epigenetic modulation by SDH and HIF mutations, and c) the epistatic interaction between in vivo hypoxia and HIF mutation (cyanotic congenital heart disease and paraganglioma, NEJM, 2018).
研究兴趣
论文共 112 篇作者统计合作学者相似作者
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bioRxiv : the preprint server for biology (2024)
Xufeng Chen,Qiao Lu,Hua Zhou, Jia Liu,Bettina Nadorp,Audrey Lasry,Zhengxi Sun, Baoling Lai,Gergely Rona, Jiangyan Zhang,Michael Cammer,Kun Wang,
Qiao Lu,Xufeng Chen,Hua Zhou,Jia Liu,Bettina Nadorp,Audrey Lasry,Zhengxi Sun, Jiangyan Zhang,Michael Cammer,Kun Wang,Zoe Ciantra, Jia You,
Journal of Immunologyno. 1 (2023): 89.12-89.12
Maite Calucho,Ziming Cheng,Hoàng Nguyên,Ahmad Al Shihabi,Hector Gonzalez-Cantu, Qing Guo,Maneesha Thaker,Nicole Bechmann, Graeme Eisenhofer,Yanli Ding,Patricia L.M. Dahia,Alice Soragni
Cancer Researchno. 7_Supplement (2023): 195-195
Nature Communicationsno. 1 (2023): 123-123
Patricia L.M. Dahia,Ke Hao, John Rogus, Christian Colin, Miguel A.G. Pujana, Ken Ross, Danielle Magoffin,Neil Aronin,Alberto Cascon, César Y. Hayashida,Cheng Li,Sérgio P.A. Toledo,
crossref(2023)
Patricia L.M. Dahia, Ke Hao, John Rogus, Christian Colin, Miguel A.G. Pujana, Ken Ross, Danielle Magoffin,Neil Aronin, Alberto Cascon, César Y. Hayashida,Cheng Li, Sérgio P.A. Toledo,
crossref(2023)
Zhijun Qiu, Jihane Khalife,An-Ping Lin,Purushoth Ethiraj,Carine Jaafar,Lilly Chiou, Gabriela Huelgas-Morales, Sadia Aslam,Shailee Arya,Yogesh K Gupta,Patricia L M Dahia,Ricardo C T Aguiar
bioRxiv : the preprint server for biology (2023)
Endocrine-related Cancerno. 4 (2023)
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