基本信息
浏览量:4
![](https://originalfileserver.aminer.cn/sys/aminer/icon/show-trajectory.png)
个人简介
My lab uses the specific strengths of two model systems (C.elegans and mice) to reveal the gene regulatory mechanisms that control motor neuron development and function. To reveal such mechanisms we employ novel methodology, such as whole genome sequencing, CRISPR genome editing, ATAC-seq and cell type-specific transcriptome profiling. Our laboratory aims to systematically test whether the function of the gene regulatory factors we discover in C.elegans is conserved across phylogeny using mouse genetics and novel genomic approaches.
A detailed understanding of how the motor neurons develop and function may provide novel entry points into the etiology, diagnosis or treatment of motor neuron disorders, such as spinal muscular atrophy (SMA) and amyotrophic lateral sclerosis (ALS). From the basic science perspective, our research will reveal novel transcription factors, their targets and the cis-regulatory elements (motifs) through which these factors act. Such decoding of cis-regulatory information is a vital step toward understanding genome function.
A detailed understanding of how the motor neurons develop and function may provide novel entry points into the etiology, diagnosis or treatment of motor neuron disorders, such as spinal muscular atrophy (SMA) and amyotrophic lateral sclerosis (ALS). From the basic science perspective, our research will reveal novel transcription factors, their targets and the cis-regulatory elements (motifs) through which these factors act. Such decoding of cis-regulatory information is a vital step toward understanding genome function.
研究兴趣
论文共 64 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGYno. Pt A (2024): 35-47
Catarina Catela, Stavroula Assimacopoulos, Yihan Chen, Konstantinos Tsioras,Weidong Feng,Paschalis Kratsios
bioRxiv : the preprint server for biology (2024)
Catarina Catela, Stavroula Assimacopoulos, Yihan Chen, Konstantinos Tsioras,Weidong Feng,Paschalis Kratsios
crossref(2024)
bioRxiv the preprint server for biology (2024)
bioRxiv the preprint server for biology (2024)
crossref(2024)
Catarina Catela, Stavroula Assimacopoulos, Yihan Chen, Konstantinos Tsioras,Weidong Feng,Paschalis Kratsios
biorxiv(2024)
STAR Protocolsno. 3 (2024): 103133-103133
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn