Dr. Bernatchez’s research program studies and elaborates new therapeutic avenues for human pathologies caused by blood vessel disorders, such as endothelial dysfunction, atherosclerosis, vascular inflammation, hypertension, Marfan syndrome and rare types of muscular dystrophies characterized by tissue oedema. Additionally, his team studies the dynamic interplay between solid cancer tumors and their vascular blood supply through angiogenesis, and how this can be used for therapies. Many of his publications rely on the use of genetically-engineered models of disease, while cell biology experiments often focus on studying proteins localized in caveole, small membrane invaginations of the plasma membrane, such as endothelial Nitric Oxide synthase (eNOS), caveolin, Dysferlin, Myoferlin and Fibrillin.