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My research focuses on determining the functions and activation mechanisms of cytoplasmic Nod-like receptors (NLRs). NLRs modulate several anti-microbial functions including the activation of NF-kB and inflammasomes, a multimeric complex consisting of an NLR member together with adaptor ASC and pro-Caspase-1. The NLRP3 inflammasome has been extensively studied largely due to its’ roles in infectious and inflammatory disorders. However, the activation mechanisms of NLRP3 inflammasome remain ambiguous. We are interested in understanding how cellular metabolic pathways impact inflammasome activity. Our recent studies demonstrated cellular cholesterol transport as a key homeostatic mechanism regulating the NLRP3 inflammasome thereby highlighting a new perspective on the metabolic control of inflammasome. We are now interested in further characterizing the cholesterol transport pathways to decipher how they impact inflammasome activation and cellular metabolism, and whether these pathways might affect immune responses to pathogenic and ‘sterile’ stimuli. Our studies would lead to the identification of targets that calibrate immune responses to maintain cellular homeostasis.
Research Interests
Papers共 75 篇Author StatisticsCo-AuthorSimilar Experts
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Stuart Leishman, Najd M. Aljadeed, Liyunhe Qian,Shamshad Cockcroft, Jacques Behmoaras,Paras K. Anand
Cell Reportsno. 8 (2024): 114516-114516
STAR Protocolsno. 2 (2024): 103054-103054
bioRxiv (Cold Spring Harbor Laboratory) (2023)
Trends in Immunologyno. 12 (2022): 978-989
Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature (2022)
ImmunoHorizonsno. 8 (2022): 642-659
Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature (2022)
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