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个人简介
I have been the principal Investigator of a number of Research Projects regarding paediatric patients affected by primary and acquired immune deficiencies. After my graduation in Medicine I have been always interested in understanding the basis of the primary and acquired immune deficiencies in children. During my career I’ve been following several students and MD in their research projects and now I am the leader of a group of young MD and PhD researchers at Children Hospital Bambino Gesù.I
In the last 15 years I have been working on the immune responses in different model of immune deficiencies. I took the opportunity in the 2009 to investigate the biomarkers of immune responses upon the H1N1 vaccination in HIV infected children. Moreover in 2012 I investigated the suboptimal immune responses of Kidney transplanted patients under immune suppressive therapy and HIV infected children upon the seasonal . From 2008 I am the PI of the PEDVAC trial. With this study we evaluated for the first time the safety and the immunogenicity of a DNA therapeutic vaccination in vertically HIV-infected children. This activity has produced a highly quoted publication in International Peer reviewed Journals (see list of publications below) and has been an important instrument for the development of international collaborations in the field of Paediatric AIDS. I am a lead immunological investigator of a multi-institutional international project known as Epiical (Early-treated Perinatally HIV-infected Individuals: Improving Children’s Actual Life with Novel Immunotherapeutic Strategies), to induce HIV viral remission through novel immunotherapeutic strategies (www.epiical.org). The current application builds logically on my prior work. I have been collaborating with Dr Persaud at the John Hopkins University for the past 4 years in the EPIICAL project to investigate viro-immunological features of perinatally HIV infected children on ART. I’m co PI in 2 different NIH grant, one in collaboration with Savita Pahwa at the University of Miami, to understand the role of standard vaccines on the establishment of the reservoir (GRANT_NUMBER: 1R01AI127347-01) The second project co-leaded with Jintanat Ananworanich granted by the National Institute of Allergy and Infectious (GRANT_NUMBER: U01AI135941) aims to evaluate the possibility to target HIV reservoirs in children with HIVIS DNA and MVA-CMDR vaccines.
研究兴趣
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JAIDS Journal of Acquired Immune Deficiency Syndromes (2012)
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