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The microenvironment surrounding carcinoma cells influences cell behavior through complex interactions of biochemical factors, matrix architecture and matrix mechanical properties. Our research focuses on understanding the molecular mechanisms by which the stromal extracellular matrix and stromal cell populations influence epithelial cell behavior in cancer. We are particularly interested in how these factors influence disease progression and resistance to therapeutic intervention in breast and pancreas cancer. We utilize advanced quantitative imaging, cell and matrix mechanics, tissue engineered 3D microenvironments as well as cell and molecular biology techniques to gain a quantitative understanding of cancer cells behavior and develop novel technologies and therapeutic strategies for cancer diagnosis and treatment.
Focus Areas: Quantitative cancer biology, Cell-matrix interactions, Signal transduction, Mechanotransduction, Advanced optical imaging/Biophotonics
The microenvironment surrounding carcinoma cells influences cell behavior through complex interactions of biochemical factors, matrix architecture and matrix mechanical properties. Our research focuses on understanding the molecular mechanisms by which the stromal extracellular matrix and stromal cell populations influence epithelial cell behavior in cancer. We are particularly interested in how these factors influence disease progression and resistance to therapeutic intervention in breast and pancreas cancer. We utilize advanced quantitative imaging, cell and matrix mechanics, tissue engineered 3D microenvironments as well as cell and molecular biology techniques to gain a quantitative understanding of cancer cells behavior and develop novel technologies and therapeutic strategies for cancer diagnosis and treatment.
Focus Areas: Quantitative cancer biology, Cell-matrix interactions, Signal transduction, Mechanotransduction, Advanced optical imaging/Biophotonics
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Hongrong Zhang, Guhan Qian, Zhongming Chen,Branden Moriarity,Ingunn Stromnes,David Odde,Paolo Provenzano
CANCER RESEARCHno. 2 (2024)
bioRxiv (Cold Spring Harbor Laboratory) (2024)
CANCER RESEARCHno. 2 (2024)
CANCER RESEARCHno. 2 (2024)
CANCER RESEARCHno. 2 (2024)
Biophysical journalno. 16 (2023): 3369-3385
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