Research areas include cardiovascular and cancer epidemiology, development and validation of prognostic models, research methodology, meta-analysis, and experimental clinical trials. Research has mainly focused on the planning and execution of observational and experimental studies, applying statistical methods to observational and experimental multicentric epidemiological studies, and meta-analyses using aggregated or individual data. Publications:260 original articles (H-index 58), two monographs, and numerous abstracts presented at national and international congresses.