After her PhD at the University of Padua (Italy), Paola Picotti joined as a postdoc the group of Ruedi Aebersold at ETH Zurich, where she developed targeted proteomic technologies based on mass spectrometry. In 2011, she was appointed Assistant Professor at the Institute of Biochemistry of ETHZ and in 2017 tenured Associate Professor at the Institute of Molecular Systems Biology at ETHZ.

Major contributions of the Picotti group include the development of structural proteomics technologies to probe in situ protein structural changes, the characterization of the determinants of proteome thermostability, the large-​scale identification of protein small molecule interactions and the discovery of regulators of toxic proteins involved in Parkinson’s disease.

Dr. Picotti was awarded the Latsis Prize, the Cotter Award of the US HUPO, the SGMS award, the EMBO Young Investigator Award, the Friedrich Miescher Award, the Juan-​ Pablo Albar award of the European Proteome Association, an ERC Starting grant, an ERC Consolidator Grant and the EMBO Gold Medal.