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My lab has focused on understanding the mechanisms that determine whether T cells are activated or tolerized in vivo. We use a variety of transgenic and gene knock out mouse models to evaluate the molecular pathways that govern T cell fate. In particular, we examine how to promote T cell responses to tissues, with a goal to understand and control autoimmune and anti-tumor immune responses.
Our recent studies have examined novel ways that dendritic cells are programmed to influence T cell function in vivo. In addition we are focussed on how the tissue or tumor microenvironment can have a significant impact on T cell responses.
Importantly, my interests have also expanded to establishing an immune therapy platform. My group has developed the ability to grow tumor infiltrating T cells and characterize their properties. We have also coordinated clinical trials and are building towards a comprehensive program in immune therapy.
Our recent studies have examined novel ways that dendritic cells are programmed to influence T cell function in vivo. In addition we are focussed on how the tissue or tumor microenvironment can have a significant impact on T cell responses.
Importantly, my interests have also expanded to establishing an immune therapy platform. My group has developed the ability to grow tumor infiltrating T cells and characterize their properties. We have also coordinated clinical trials and are building towards a comprehensive program in immune therapy.
Research Interests
Papers共 528 篇Author StatisticsCo-AuthorSimilar Experts
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ONCOIMMUNOLOGYno. 1 (2024): 2349347-2349347
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CANCER DISCOVERYno. 6 (2024): 1048-1063
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Nicolas Jacquelot, Le Xiong, Wang H.J. Cao,Qiutong Huang, Huiyang Yu,Azin Sayad,Casey J.A. Anttila,Tracey M. Baldwin,Peter F. Hickey,Daniela Amann-Zalcenstein,Pamela S. Ohashi,Stephen L. Nutt,
Mucosal Immunologyno. 3 (2024): 371-386
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