基本信息
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Bio
Phillip A. Low, M.D. has a long-standing research focus on clinical research into the cause and treatment of autonomic disorders. Efforts have been concentrated on three major areas.
Dr. Low's research has been continuously funded by the National Institutes of Health (NIH) over the past 30 years.
Dr. Low heads an NIH-funded program project on MSA. The hallmark of MSA is gial cytoplasmic inclusions due to aggregation of microfibrils of an abnormal protein (alpha-synuclein). The team has been elucidating how this aggregation leads to degeneration of nearby neurons.
Importantly, they have sought approaches that prevent or reverse this process and have tried to apply it to human subjects with MSA. They have an ongoing double-blind, placebo-controlled clinical treatment trial of MSA with rifampicin. Dr. Low heads this NIH-funded, multicenter national study of 100 subjects who are treated for 12 months. Another treatment trial approach is that of mesenchymal stem cells (MSC), based on the hypothesis that MSCs can provide the necessary growth factors that are deficient (due to glial cytoplasmic inclusions).
Dr. Low and his team are also evaluating novel methods to treat other complications of MSA, including orthostatic hypotension. In orthostatic hypotension, the orthostatic fall in blood pressure is coupled with excessively high blood pressure when the person lies down (supine hypertension). Dr. Low and his colleagues are exploring novel approaches, based on their research, that can improve standing blood pressure without aggravating supine hypertension. They also have an ongoing study on the natural history of MSA.
Research Interests
Papers共 720 篇Author StatisticsCo-AuthorSimilar Experts
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Tina Liu, Monica Krause,Negin Badihian,William Harmsen,Lauren Jackson, Marianna Suarez,Eduardo Benarroch,Paola Sandroni,Phillip Low,Wolfgang Singer,Elizabeth Coon
Movement disorders clinical practice (2024)
Brain : a journal of neurologyno. 7 (2024): 2440-2448
MOVEMENT DISORDERS CLINICAL PRACTICEno. 3 (2024): 220-226
Clinical Autonomic Researchpp.1-5, (2024)
Neurologyno. 17_supplement_1 (2024)
Michele Potashman, Lila Brady,Susan Durham,Victoria Wirtz,Gilbert L'Italien,Vladimir Coric, Gunter Hoeglinger,Horacio Kaufmann,Phillip Low,Nikolaus McFarland,Wassilios Meissner,Patricio Millar Vernetti,
NEUROLOGYno. 17 (2023)
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