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There have been significant developments in cardiac care and treatment, and yet many patients who survive a heart attack will subsequently go into heart failure. Is the mishandling of oxygen in the body a contributing factor? When life-sustaining oxygen is improperly handled within a cell, free radicals are created – a new, toxic species that tends to be removed under normal conditions. However, if the body’s natural defenses are lowered, they can be detrimental.
Dr. Singal’s pioneering studies have led the way in understanding how various antioxidants have the potential to prevent or treat the damage associated with free radical induced oxidative stress. Different animal models of heart failure (chronic, subchronic) are utilized to examine cell, sub-cell and molecular changes to understand the pathogenesis of heart failure due to a variety of causes.
Our working hypothesis is that “free-radical based oxidative stress contributes to the pathogenesis of heart failure”.
Dr. Singal’s pioneering studies have led the way in understanding how various antioxidants have the potential to prevent or treat the damage associated with free radical induced oxidative stress. Different animal models of heart failure (chronic, subchronic) are utilized to examine cell, sub-cell and molecular changes to understand the pathogenesis of heart failure due to a variety of causes.
Our working hypothesis is that “free-radical based oxidative stress contributes to the pathogenesis of heart failure”.
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Canadian journal of physiology and pharmacologyno. 1 (2024): 14-25
CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGYno. 1 (2024): 14-25
Sara M. Telles-Langdon, Vibuhti Arya, Paris R. Haasbeek,David Y.C. Cheung,Cameron R. Eekhoudt, Lana Mackic, Ashley N. Bryson,Sonu S. Varghese,J. Alejandro Austria,James A. Thliveris,Harold M. Aukema,Amir Ravandi,
CJC Open (2024)
Nitric Oxide: From Research to TherapeuticsAdvances in Biochemistry in Health and Diseasepp.127-145, (2023)
Antonio Viana do Nascimento Filho,Filipe F Stoyell-Conti,Gauri Akolkar, Victor Hugo M de Miranda,Pawan Singal,Maria Cláudia Irigoyen,Kátia De Angelis,Danielle da Silva Dias
Canadian Journal of Cardiologyno. 10 (2022): S161-S161
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