基本信息
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Bio
Major Publications:
➢ Lesnik P, Rouis M, Skarlatos S, Kruth HS, and Chapman MJ. Uptake of exogenous free cholesterol induces upregulation of tissue factor expression in human monocyte-derived macrophages. Proc Natl Acad Sci USA, 1992, 89: 10370.
➢ Lesnik P, Haskell CA, and Charo I. Decreased atherosclerosis in CX3CR1-/- mice reveals a role for fractalkine in atherogenesis. J Clin Invest , 2003, 111: 333.
➢ Huby T, Doucet C, Dachet C, Ouzilleau,B, Ueda Y, Afzal V, Rubin E, Chapman J, Lesnik P. Knockdown expression and hepatic deficiency reveal an atheroprotective role for SR-BI in liver and peripheral tissues. J Clin Invest, 2006, 116, 2767.
➢ Gautier E, Huby T, B Ouzilleau B, Doucet C, Saint-Charle F, Gremy G; Chapman J and Lesnik P. Enhanced immune system activation and arterial inflammation accelerates atherosclerosis in lupus-prone mice. Arterioscler Thromb Vasc Biol, 2007, 27:1625.
➢ Gautier EL, Huby T, Saint-Charles F, Ouzilleau B, Chapman MJ and Lesnik P. Enhanced dendritic cell survival attenuates lipopolysaccharide-induced immunosuppression and increases resistance to lethal endotoxic shock. J Immunol, 2008, 27:1625.
➢ Gautier EL, Huby T, Witztum JL, Ouzilleau B, Miller ER, Saint-Charles F, Aucouturier P, Chapman MJ and Lesnik P. Macrophage survival exerts divergent effects on atherogenesis as a function of lesion stage. Circulation, 2009, 119: 1795
➢ Gautier EL, Huby T, Saint-Charles F, Ouzilleau B, Pirault J, Deswaerte V, Ginhoux F, E.R. M, Witztum JL, Chapman MJ, Lesnik P. Conventional Dendritic Cells at the Crossroads between Immunity and Cholesterol Homeostasis in Atherosclerosis. Circulation, 2009, 119: 2367.
➢ Nordestgaard BG, Chapman MJ, Ray K, Borén J, Andreotti F, Watts GF, Ginsberg H, Amarenco P, Catapano A, Descamps OS, Fisher E, Kovanen PT, Kuivenhoven JA, Lesnik P et al.. Lipoprotein(a) as a cardiovascular risk factor: current status. Eur Heart J. 2010, 23:2844.
➢ Chapman MJ, Ginsberg HN, Amarenco P, Andreotti F, Borén J, Catapano AL, Descamps OS, Fisher E, Kovanen PT, Kuivenhoven JA, Lesnik P et al. Triglyceride-rich lipoproteins and high-density lipoprotein cholesterol in patients at high risk of cardiovascular disease: evidence and guidance for management. Eur Heart J. 2011 Jun;32(11):1345-61
➢ Shearn AU, Deswaerte V, Gautier EL, Saint-Charles F, Pirault J, Bouchareychas L, Rucker EB, Sophie S, Chapman MJ, Jessup W, Huby T and Lesnik P. Bcl-x inactivation in macrophages is associated with accelerated progression of advanced atherosclerotic lesions in Apoe-/- mice. Arterioscler Thromb Vasc Biol, 2012 May;32(5):1142-9.
➢ Poupel L, Boissonnas A, Hermand P, Dorgham K, Guyon E, Auvynet C, Charles FS, Lesnik P et al. Pharmacological Inhibition of the Chemokine Receptor, CX3CR1, Reduces Atherosclerosis in Mice. Arterioscler Thromb Vasc Biol. 2013, 33:2297-305.
➢ Gautier EL, Ivanov S, Lesnik P, Randolph GJ. Local apoptosis mediates clearance of macrophages from resolving inflammation in mice. Blood. 2013, 122:2714.
➢ Gilibert S, Galle-Treger L, Moreau M, Saint-Charles F, Costa S, Ballaire R, Couvert P, Carrié A, Lesnik P, Huby T. Adrenocortical scavenger receptor class B type I deficiency exacerbates endotoxic shock and precipitates sepsis-induced mortality in mice. J Immunol. 2014 Jul 15;193(2):817-26
➢ Anjani K, Lhomme M, Sokolovska N, Poitou C, Aron-Wisnewsky J, Bouillot JL, Lesnik P et al . Circulating phospholipid profiling identifies portal contribution to NASH signature in obesity. J Hepatol. 2015 Apr;62(4):905-12
➢ Bouchareychas L, Pirault J, Saint-Charles F, Deswaerte V, Le Roy T, Jessup W, Giral P, Le Goff W, Huby T, Gautier EL and Lesnik P. Promoting macrophage survival delays progression of pre-existing atherosclerotic lesions through macrophage-derived apoE. Cardiovasc Res. 2015;108:111-23
➢ Villette R, KC P, Béliard S, Salas Tapia M.F, Rainteau D, Guerin M, Lesnik P. Unraveling host-gut microbiota dialogue and its impact on cholesterol levels. Front. Pharmacol. doi: 10.3389/fphar.2020.00278
➢ Le Roy T, Lécuyer E, Chassaing B, Rhimi M, Lhomme M, Boudebbouze S, Ichou F, Haro Barceló J, Huby T, Guerin M, Giral P, Maguin E, Kapel N, Gérard P, Clément K, Lesnik P. The intestinal microbiota regulates host cholesterol homeostasis. BMC Biol. 2019 Nov 27;17(1):94
➢ Tran S, Baba I, Poupel L, Dussaud S, Moreau M, Gélineau A, Marcelin G, Magréau-Davy E, Ouhachi M, Lesnik P, Boissonnas A, Le Goff W, Clausen BE, Yvan-Charvet L, Sennlaub F, Huby T, Gautier EL.Impaired Kupffer cell self-renewal alters the liver response to lipid overload during non-alcoholic steatohepatitis. Immunity. 2020;S1074-7613(20)30233-8.
➢ Toubal A, Kiaf B, Beaudoin L Cagninacci L, Rhimi M, Fruchet B, da Silva J, Corbett A, Simoni Y, Lantz O, Rossjohn J, McCluskey J, Lesnik P, Maguin E, and Lehuen A. Mucosal-Associated Invariant T cells promote inflammation and intestinal dysbiosis leading to metabolic dysfunction during obesity. Nat Commun. 2020 Jul 24;11(1):3755.
Research Interests
Papers共 134 篇Author StatisticsCo-AuthorSimilar Experts
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Microbiomeno. 1 (2024): 1-19
T. Pirbay,V. Carreau,M. Guérin,E. Frisdal,P. Lesnik,A. Mondelli,P. Giral, O. Bluteau, M. Georget,R. Bittar,D. Bonnefont-Rousselot,E. Bruckert,
Archives of Cardiovascular Diseasesno. 1 (2024): S107-S108
MICROBIOMEno. 1 (2024)
Fanny Urbain,Maharajah Ponnaiah,Farid Ichou,Marie Lhomme, Clément Materne,Sophie Galier,Julien Haroche,Eric Frisdal,Alexis Mathian, Herve Durand,Micheline Pha,Miguel Hie,
EBioMedicine (2023): 104802-104802
Frontiers in pediatrics (2023): 1120008
European Heart Journalno. Supplement_2 (2023)
Fanny Urbain,Maharajah Ponnaiah,Farid Ichou,Marie Lhomme, Clément Materne,Sophie Galier,Julien Haroche,Eric Frisdal,Alexis Mathian, Herve Durand,Micheline Pha,Miguel Hie,
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Atherosclerosis (2023): S59-S59
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Author Statistics
#Papers: 139
#Citation: 5938
H-Index: 36
G-Index: 76
Sociability: 7
Diversity: 0
Activity: 1
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