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Peter Lansdorp is a pioneer in studies of blood-forming stem cells, telomeres and the biology of ageing with a track record of developing novel ideas and approaches to address diverse scientific questions. As such, Peter Lansdorp has made contributions to multiple, apparently distinct research fields. He has published over 300 papers, a hundred of which have been cited more than a 100 times (total citations > 40,000; h-index=108). From 2011-2016 he was the Founding Director of the European Research Institute for the Biology of Ageing (ERIBA) at the University Medical Center Groningen and the University of Groningen in the Netherlands. He returned to UBC in 2017.
As a graduate student Peter Lansdorp discovered tetrameric antibody complexes. This discovery has found numerous applications including cell separation techniques (commercialized by StemCell in Vancouver). For his research on human hematopoietic stem cells he developed assays, monoclonal antibodies (such as anti-CD34), cell culture media and cell separation techniques that are still in widespread use. In 1994 his lab found that the length of telomere repeats in hematopoietic cells decreases with proliferation in vitro and with age in vivo. He subsequently developed quantitative fluorescence in situ hybridization (Q-FISH) techniques, using directly labeled peptide nucleic acid (PNA) probes, to measure the length of telomere repeats in chromosomes and cells. Most laboratories involved in telomere research use PNA probes according to the methods developed by the Lansdorp laboratory. In 2005 he founded a Vancouver company (Repeat Diagnostics Inc.) that provides telomere length measurements as a diagnostic service to clinicians worldwide looking after patients with aplastic anemia, idiopathic pulmonary fibrosis and other “telomere” disorders. A current interest in his laboratory is related to the possibility that gene expression and cell fate are regulated in part by chromatin differences between sister chromatids. In order to test the “silent sister” hypothesis his laboratory developed a single cell DNA strand sequencing method. The Strand-seq method has widespread applications in studies of genetics, aging and cancer.
As a graduate student Peter Lansdorp discovered tetrameric antibody complexes. This discovery has found numerous applications including cell separation techniques (commercialized by StemCell in Vancouver). For his research on human hematopoietic stem cells he developed assays, monoclonal antibodies (such as anti-CD34), cell culture media and cell separation techniques that are still in widespread use. In 1994 his lab found that the length of telomere repeats in hematopoietic cells decreases with proliferation in vitro and with age in vivo. He subsequently developed quantitative fluorescence in situ hybridization (Q-FISH) techniques, using directly labeled peptide nucleic acid (PNA) probes, to measure the length of telomere repeats in chromosomes and cells. Most laboratories involved in telomere research use PNA probes according to the methods developed by the Lansdorp laboratory. In 2005 he founded a Vancouver company (Repeat Diagnostics Inc.) that provides telomere length measurements as a diagnostic service to clinicians worldwide looking after patients with aplastic anemia, idiopathic pulmonary fibrosis and other “telomere” disorders. A current interest in his laboratory is related to the possibility that gene expression and cell fate are regulated in part by chromatin differences between sister chromatids. In order to test the “silent sister” hypothesis his laboratory developed a single cell DNA strand sequencing method. The Strand-seq method has widespread applications in studies of genetics, aging and cancer.
Research Interests
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Kasmintan A. Schrader,Vahid Akbari,Vincent Hanlon, Tiffany Leung,Katherine Dixon,Kieran O'Neill, Alexandra Roston, Lilian Cordova, Karen Wong,Alexandra Fok,David F. Schaeffer,Daniel John Renouf,
Journal of Clinical Oncologyno. 16_suppl (2024): 10516-10516
iScienceno. 6 (2024): 109981-109981
EUROPEAN JOURNAL OF HUMAN GENETICS (2024): 626-626
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Genetics in Medicine Openno. 1 (2023): 100461-100461
bioRxiv (Cold Spring Harbor Laboratory) (2023)
iScienceno. 7 (2023): 107053
bioRxiv (Cold Spring Harbor Laboratory) (2023)
METHODS (2022): 64-72
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