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Acute and chronic autoimmune diseases are a huge burden to the NHS. Checkpoint inhibitors that suppress normal mechanisms that maintain self-tolerance, have been effective in revealing CD8 driven immune responses against cancers with high mutation loads, but at the cost of off target, primarily CD4 driven, autoimmunity which can be lethal. In his MRC funded research he has identified OX40 blockade as being effective in abrogating this “acute” inflammation without compromising anti-tumour immunity driven by CD8 T cells.
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Papers共 62 篇Author StatisticsCo-AuthorSimilar Experts
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Journal of Hepatology (2020): S201-S202
Cancer Researchno. 5 (2017): 1083-1096
semanticscholar(2017)
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