基本信息
views: 0
![](https://originalfileserver.aminer.cn/sys/aminer/icon/show-trajectory.png)
Bio
We are interested in how gene dosage imbalance causes human neurodevelopmental disorders such as autism spectrum disorders (ASDs) and intellectual disability. Understanding these disorders on molecular, cellular, neural circuit, and behavioral levels will provide therapeutic avenues and ultimately improve patients’ quality of life. We model gene dosage imbalance in a pair of syndromic ASDs: Smith−Magenis Syndrome (SMS), caused by loss of a Retinoic Acid Induced 1 (RAI1), and Potocki−Lupski Syndrome (PTLS), caused by gain of RAI1.
RAI1 is a chromatin-interacting protein that regulates many genes involved in neural circuit assembly. We are also interested in its interacting partner TCF20, which is mutated in patients who suffer from intellectual disability and ASDs.
RAI1 is a chromatin-interacting protein that regulates many genes involved in neural circuit assembly. We are also interested in its interacting partner TCF20, which is mutated in patients who suffer from intellectual disability and ASDs.
Research Interests
Papers共 22 篇Author StatisticsCo-AuthorSimilar Experts
By YearBy Citation主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Sundus Javed, Yao-Tang Chang, Y.-S. Cho,Yu-Ju Lee, Hui S. Chang,Minza Haque,Yu‐Cheng Lin,Wei-Hsiang Huang
eLife (2023)
Ya-Ting Chang, Max Kowalczyk,P. Michelle Fogerson,Yu-Ju Lee,Minza Haque,David C. Wang, A. DeNardo,Marc Tessier-Lavigne,John R. Huguenard,Eliza L. Adams,Liqun Luo,Wei-Hsiang Huang
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICAno. 52 (2022)
Cited6Views0Bibtex
6
0
The Journal of biological chemistryno. 1 (2022): 102728-102728
Cited0Views0Bibtex
0
0
Load More
Author Statistics
Co-Author
Co-Institution
D-Core
- 合作者
- 学生
- 导师
Data Disclaimer
The page data are from open Internet sources, cooperative publishers and automatic analysis results through AI technology. We do not make any commitments and guarantees for the validity, accuracy, correctness, reliability, completeness and timeliness of the page data. If you have any questions, please contact us by email: report@aminer.cn